Disassembly of SR-BI-bound spherical HDL

Stable Identifier
R-HSA-349638
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Spherical HDL particles bound to the cell-surface SR-BI receptor are disassembled, with the release of pre-beta HDL (essentially apoA-I lipoprotein with a few molecules of bound lipid) and the cellular uptake of the bulk of the HDL-associated cholesterol, cholesterol esters, phospholipids, and triacylglycerols. The specificity and efficiency of this process has been demonstrated through a variety of studies in tissue culture model systems (Rigotti et al. 2003; Silver and Tall 2001). The process is annotated here as a concerted event occuring at the cell surface but its molecular details remain incompletely defined and it is possible that the HDL particle is internalized while undergoing disassembly.

Literature References
PubMed ID Title Journal Year
12788804 The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues

Rigotti, A, Miettinen, HE, Krieger, M

Endocr Rev 2003
11561168 The cellular biology of scavenger receptor class B type I

Silver, DL, Tall, AR

Curr Opin Lipidol 2001
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