spherical HDL and SR-BI receptor form a complex at the cell surface

Stable Identifier
R-HSA-349637
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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An extracellular spherical HDL particle binds to the plasma membrance-associated SR-BI receptor with high affinity (Murao et al. 1997). In the body SR-BI receptors are abundant on the surfaces of steroidogenic cells in the adrenal glands and gonads, and on hepatocytes. SR-BI thus appears to play a central role in cholesterol uptake for steroid hormone synthesis and for bile acid synthesis and cholesterol excretion (Rigotti et al. 2003; Silver and Tall 2001).

Literature References
PubMed ID Title Journal Year
9211901 Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes

Murao, K, Terpstra, V, Green, SR, Kondratenko, N, Steinberg, D, Quehenberger, O

J Biol Chem 1997
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