Reactome | FLIP(S) [cytosol]

FLIP(S) [cytosol]

Stable Identifier

R-HSA-3465357

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CASP8 and FADD-like apoptosis regulator Isoform 2, CLARP2, MRIT beta-1, CASH beta

Locations in the PathwayBrowser for interactor UniProt:P50591 TNFSF10

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External Reference Information

External Reference

UniProt:O15519-2 CFLAR

Gene Names

CFLAR, CASH, CASP8AP1, CLARP, MRIT

Participates

as an input of

FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)

as a component of

DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)

This entity regulates

Negatively

Inferred To

CASP9 [cytosol] (Bos taurus)

CASP9 [cytosol] (Canis familiaris)

CASP9 [cytosol] (Sus scrofa)

FLIP(S) [cytosol] (Gallus gallus)

Cflar [cytosol] (Mus musculus)

Cflar [cytosol] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000003402

ENSEMBL

ENST00000440180, ENST00000342795, ENSP00000339335, ENST00000341222, ENST00000479953, ENSP00000312455, ENSP00000413270, ENSP00000406775, ENST00000423241, ENSP00000342809, ENST00000309955, ENSP00000399420, ENST00000341582, ENST00000457277, ENST00000443227, ENSP00000471805, ENSP00000345807, ENSG00000003402, ENSP00000411535

HPA

ENSG00000003402-CFLAR

GeneCards

CFLAR

PRO

O15519

Pharos - Targets

O15519

PDB

8YD8, 7LXC, 3H11, 6M6O, 2N5R, 8YBX, 8YD7, 3H13, 7DEE

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14790 CASP8	8	CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(1-374) [cytosol] (R-HSA-3465404)	0.744	10
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.718	6
UniProt:Q92851 CASP10	4	CASP10(1-521) [cytosol] (R-HSA-933453) CASP10(416-521) [cytosol] (R-HSA-933455) CASP10(1-219) [cytosol] (R-HSA-933454) CASP10(220-415) [cytosol] (R-HSA-933458)	0.65	3
UniProt:P50591 TNFSF10	1	TNFSF10 [extracellular region] (R-HSA-66186)	0.527	2
UniProt:Q00G26 PLIN5			0.527	2

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