KAT5 HAT complex acetylates TCF4 gene at histone H4

Stable Identifier
R-HSA-3451147
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
KAT5 HAT complex acetylates TCF4 gene at histone H4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TIP49, TRRAP, TCF7L2 (TCF4) and KAT5 are present at the ITF-2 promoter in vivo in HEK293 cells as assessed by ChIP. Expression of a dominant negative form of TIP49 in rat epithelial cells is associated with a decrease in both histone H4 acetylation at the ITF-2 promoter and in ITF-2 gene expression. These results suggest that a TIP49-containing HAT complex may play a role in promoting WNT-responsive ITF-2 expression, although more functional studies will be required to elucidate the mechanism (Feng et al, 2003).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

histone acetyltransferase activity of TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm]

Physical Entity
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Homo sapiens)
Activity
histone acetyltransferase activity (GO:0004402)
Inferred From
KAT5 HAT complex acetylates TCF4 (ITF-2) gene at histone H4 (Homo sapiens)
Authored
Rothfels, K  (2013-05-30)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2013-05-16)
Cite Us!