TIP49, TRRAP, TCF7L2 (TCF4) and KAT5 are present at the ITF-2 promoter in vivo in HEK293 cells as assessed by ChIP. Expression of a dominant negative form of TIP49 in rat epithelial cells is associated with a decrease in both histone H4 acetylation at the ITF-2 promoter and in ITF-2 gene expression. These results suggest that a TIP49-containing HAT complex may play a role in promoting WNT-responsive ITF-2 expression, although more functional studies will be required to elucidate the mechanism (Feng et al, 2003).
histone acetyltransferase activity of TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm]
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