HSBP1 binds HSF1 trimer

Stable Identifier
R-HSA-3371582
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Heat shock factor binding protein 1 (HSBP1) is a nuclear localized hydrophobic repeat-containing protein, which interacts with trimerization domain of HSF1 and negatively regulates DNA-binding activity of HSF1. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1 (Satyal SH et al. 1998).

Literature References
PubMed ID Title Journal Year
9649501 Negative regulation of the heat shock transcriptional response by HSBP1

Satyal, SH, Chen, D, Fox, SG, Kramer, JM, Morimoto, RI

Genes Dev. 1998
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Orthologous Events
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