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HSBP1 binds HSF1 trimer
Stable Identifier
R-HSA-3371582
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1-dependent transactivation (Homo sapiens)
Attenuation phase (Homo sapiens)
HSBP1 binds HSF1 trimer (Homo sapiens)
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Heat shock factor binding protein 1 (HSBP1) is a nuclear localized hydrophobic repeat-containing protein, which interacts with trimerization domain of HSF1 and negatively regulates DNA-binding activity of HSF1. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1 (Satyal SH et al. 1998).
Literature References
PubMed ID
Title
Journal
Year
9649501
Negative regulation of the heat shock transcriptional response by HSBP1
Fox, SG
,
Morimoto, RI
,
Kramer, JM
,
Chen, D
,
Satyal, SH
Genes Dev.
1998
Participants
Input
HSBP1 hexamer [nucleoplasm]
(Homo sapiens)
HSF1 trimer [nucleoplasm]
(Homo sapiens)
Output
HSBP1:HSF1 trimer [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Attenuation phase (Homo sapiens)
Orthologous Events
HSBP1 binds HSF1 trimer (Bos taurus)
HSBP1 binds HSF1 trimer (Caenorhabditis elegans)
HSBP1 binds HSF1 trimer (Canis familiaris)
HSBP1 binds HSF1 trimer (Dictyostelium discoideum)
HSBP1 binds HSF1 trimer (Drosophila melanogaster)
HSBP1 binds HSF1 trimer (Gallus gallus)
HSBP1 binds HSF1 trimer (Mus musculus)
HSBP1 binds HSF1 trimer (Rattus norvegicus)
HSBP1 binds HSF1 trimer (Schizosaccharomyces pombe)
HSBP1 binds HSF1 trimer (Sus scrofa)
Authored
Shamovsky, V (2013-10-29)
Reviewed
Pani, B (2014-02-17)
Created
Shamovsky, V (2013-05-13)
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