HSBP1 binds HSF1 trimer

Stable Identifier
R-HSA-3371582
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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HSBP1 binds HSF1 trimer
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Heat shock factor binding protein 1 (HSBP1) is a nuclear localized hydrophobic repeat-containing protein, which interacts with trimerization domain of HSF1 and negatively regulates DNA-binding activity of HSF1. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1 (Satyal SH et al. 1998).

Literature References
PubMed ID Title Journal Year
9649501 Negative regulation of the heat shock transcriptional response by HSBP1

Satyal, SH, Chen, D, Fox, SG, Kramer, JM, Morimoto, RI

Genes Dev. 1998
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Orthologous Events
HSBP1 binds HSF1 trimer (Caenorhabditis elegans)
HSBP1 binds HSF1 trimer (Canis familiaris)
HSBP1 binds HSF1 trimer (Danio rerio)
HSBP1 binds HSF1 trimer (Dictyostelium discoideum)
HSBP1 binds HSF1 trimer (Drosophila melanogaster)
HSBP1 binds HSF1 trimer (Gallus gallus)
HSBP1 binds HSF1 trimer (Mus musculus)
HSBP1 binds HSF1 trimer (Rattus norvegicus)
HSBP1 binds HSF1 trimer (Schizosaccharomyces pombe)
HSBP1 binds HSF1 trimer (Sus scrofa)
HSBP1 binds HSF1 trimer (Xenopus tropicalis)
Authored
Shamovsky, V  (2013-10-29)
Reviewed
Pani, B  (2014-02-17)
Created
Shamovsky, V  (2013-05-13)
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