Reactome | DBC1 [nucleoplasm]

DBC1 [nucleoplasm]

Stable Identifier

R-HSA-3371479

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

KIAA1967, DBIRD complex subunit KIAA1967, Deleted in breast cancer gene 1 protein, p30 DBC

Locations in the PathwayBrowser for interactor UniProt:Q05322 VP24

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External Reference Information

External Reference

UniProt:Q8N163 CCAR2

Gene Names

CCAR2, DBC1, KIAA1967

Chain

chain:1-923

Reference Genes

BioGPS Gene:57805 CCAR2

COSMIC (genes):CCAR2 CCAR2

CTD Gene:57805 CCAR2

dbSNP Gene:57805 CCAR2

ENSEMBL:ENSG00000158941 CCAR2

HGNC:23360 CCAR2

KEGG:hsa:57805 CCAR2

Monarch:57805 CCAR2

NCBI Gene:57805 CCAR2

OMIM:607359 CCAR2

UCSC:Q8N163 CCAR2

Reference Transcript

RefSeq:NM_021174.5 CCAR2

Other Identifiers

11722676_a_at

11748940_a_at

17066733

225187_PM_at

225187_at

3089598

3089599

3089600

3089601

3089602

3089604

3089605

3089606

3089607

3089608

3089609

3089610

3089611

3089615

3089616

3089617

3089618

3089619

3089620

3089621

3089622

3089623

3089624

3089625

3089626

3089627

3089628

3089629

3089630

3089631

3089632

3089633

3089634

3089635

3089636

3089637

3089638

3089639

3089640

3089641

3089642

48581_at

57805

8145201

A_14_P101308

A_14_P128717

A_24_P38446

GE86972

GO:0000774

GO:0000785

GO:0000993

GO:0003723

GO:0004857

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005759

GO:0005819

GO:0005856

GO:0006355

GO:0006397

GO:0006915

GO:0006974

GO:0007005

GO:0008380

GO:0009411

GO:0012501

GO:0016055

GO:0016071

GO:0019899

GO:0030308

GO:0031647

GO:0032435

GO:0032784

GO:0042752

GO:0043065

GO:0043086

GO:0043226

GO:0043653

GO:0044609

GO:0045892

GO:0048511

GO:0051082

GO:0090263

GO:0090311

GO:0098772

GO:1902230

GO:2000003

HMNXSV003049195

Hs.181102.2.S1_3p_at

Hs.181102.2.S1_3p_x_at

ILMN_1699473

ILMN_1786345

ILMN_1804789

PH_hs_0033327

TC08000175.hg

TC08001835.hg

p33726

Participates

as an input of

DBC1 is phosphorylated by ATM/ART (Homo sapiens)

Other forms of this molecule

p-T454-DBC1 [nucleoplasm]

Cross References

ENSEMBL

ENST00000308511, ENST00000389279, ENSP00000373930, ENSP00000310670

OpenTargets

ENSG00000158941

HPA

ENSG00000158941-CCAR2

PRO

Q8N163

Pharos - Targets

Q8N163

GlyGen

Q8N163

PDB

8EZ6

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.769	16
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.749	9
UniProt:Q96L14 C170L			0.669	3
UniProt:Q9H4Z2 ZNF335	1	ZNF335 [nucleoplasm] (R-HSA-6810129)	0.621	5
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.564	2
UniProt:Q9Q2G4 Q9Q2G4			0.558	5
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.556	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.547	2
UniProt:Q05322 VP24			0.527	3
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.527	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	9
UniProt:Q5SW79 CE170			0.508	2
UniProt:Q8IUH3 RBM45			0.462	2
UniProt:P03366 POL			0.462	2

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