Reactome | Ub-121-H2BFS [nucleoplasm]

Ub-121-H2BFS [nucleoplasm]

Stable Identifier

R-HSA-3364028

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H2B.s K121ub

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
      - SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
        
        MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-H2BFS [nucleoplasm] (Homo sapiens)
        
        MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-H2BFS [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P57053 H2BC12L

Gene Names

H2BC12L, H2BFS, H2BS1

Chain

initiator methionine:1, chain:2-126

Reference Genes

BioGPS Gene:102724334 H2BC12L

dbSNP Gene:102724334 H2BC12L

ENSEMBL:ENSG00000234289 H2BFS

ENSEMBL:ENSG00000234289.6 H2BC12L

HGNC:4762 H2BC12L

KEGG Gene (Homo sapiens):102724334 H2BC12L

Monarch:102724334 H2BC12L

NCBI Gene:102724334 H2BC12L

UCSC:P57053 H2BC12L

Reference Transcript

RefSeq:XM_006723918.3 H2BC12L

Other Identifiers

102724334

124908234

208579_PM_x_at

208579_x_at

2946721

3923212

3923213

54145

8068898

A_23_P40470

GE553273

GO:0000786

GO:0002227

GO:0002376

GO:0003677

GO:0005198

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0019731

GO:0021762

GO:0030527

GO:0042742

GO:0043226

GO:0043229

GO:0046982

GO:0048856

GO:0050830

GO:0061844

GO:0098542

HMNXSV003040333

ILMN_1813314

PH_hs_0037388

TC21000211.hg

TC21000762.hg

g11036645_3p_x_at

Participates

as a candidate of

Histone H2B K121ub [nucleoplasm] (Homo sapiens)

Other forms of this molecule

H2BFS [extracellular region]

H2BFS [nucleoplasm]

Inferred To

LOC100498553 [nucleoplasm] (Xenopus tropicalis)

LOC116411635 [nucleoplasm] (Xenopus tropicalis)

h2bc14 [nucleoplasm] (Xenopus tropicalis)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Danio rerio)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Xenopus tropicalis)

Ub-121-H2BFS [nucleoplasm] (Rattus norvegicus)

hist2h2l [nucleoplasm] (Danio rerio)

LOC570661 [nucleoplasm] (Danio rerio)

Ub-121-HIST1H2BK [nucleoplasm] (Danio rerio)

Ub-121-HIST1H2BK [nucleoplasm] (Xenopus tropicalis)

si:ch211-113a14.29 [nucleoplasm] (Danio rerio)

h2bc21 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine at 121

Coordinate

121

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_006723981.1

GeneCards

P57053

HPA

ENSG00000234289-H2BC12L

Ensembl

ENST00000599962, ENSP00000481622, ENSG00000234289

PRO

P57053

Pharos - Targets

P57053