SET1 complex trimethylates H3K4 at the MYC gene

Stable Identifier
R-HSA-3364026
Type
Reaction
Species
Homo sapiens
Compartment
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The recruitment of SET1-type complexes at the MYC enhancer correlates with increased H3K4 trimethylation in vivo, a mark associated with active chromatin (Sierra et al, 2006). Studies in yeast have shown that H3K4 trimethylation depends on previous H2B ubiquitination by Rad6 and Bre1, which in turn are recruited to DNA by the Paf1 complex (reviewed in Shilatifard, 2006). In this context, the identification of Paf1 components as interactors with the C-terminal activation domain of beta-catenin is intriguing (Sierra et al, 2006)

Literature References
PubMed ID Title Journal Year
16510874 The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

Yoshida, T, Jones, KA, Sierra, J, Joazeiro, CA

Genes Dev. 2006
16756492 Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression

Shilatifard, A

Annu. Rev. Biochem. 2006
Participants
Participates
Catalyst Activity

histone methyltransferase activity (H3-K4 specific) of TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm]

Orthologous Events
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