Reactome | PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier

R-HSA-3343700

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

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Peroxiredoxin 6 (PRDX6) forms a heterodimer with GSTP1 (Pi Glutathione transferase) and catalyzes the reduction of hydrogen peroxide (H2O2) by glutathione to yield oxidized glutathione and water (Ralat et al. 2006, Ralat et al. 2008, Zhou et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
18358825	Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin Manevich, Y, Ralat, LA, Fisher, AB, Misquitta, SA, Colman, RF	Arch. Biochem. Biophys.	2008
23164639	Functional interaction of glutathione S-transferase pi and peroxiredoxin 6 in intact cells Lien, YC, Fisher, AB, DeBolt, K, Shuvaeva, T, Feinstein, SI, Zhou, S	Int. J. Biochem. Cell Biol.	2013
16401067	Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes Manevich, Y, Ralat, LA, Fisher, AB, Colman, RF	Biochemistry	2006