PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
R-HSA-3343700
Type
Reaction
Species
Homo sapiens
Compartment
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Peroxiredoxin 6 (PRDX6) forms a heterodimer with GSTP1 (Pi Glutathione transferase) and catalyzes the reduction of hydrogen peroxide (H2O2) by glutathione to yield oxidized glutathione and water (Ralat et al. 2006, Ralat et al. 2008, Zhou et al. 2013).

Literature References
PubMed ID Title Journal Year
18358825 Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin

Manevich, Y, Ralat, LA, Fisher, AB, Misquitta, SA, Colman, RF

Arch. Biochem. Biophys. 2008
23164639 Functional interaction of glutathione S-transferase pi and peroxiredoxin 6 in intact cells

Lien, YC, Fisher, AB, DeBolt, K, Shuvaeva, T, Feinstein, SI, Zhou, S

Int. J. Biochem. Cell Biol. 2013
16401067 Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes

Manevich, Y, Ralat, LA, Fisher, AB, Colman, RF

Biochemistry 2006
Participants
Participates
Catalyst Activity

glutathione peroxidase activity of PRDX6:GSTP1 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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