Reactome | GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier

R-HSA-3341277

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

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GPX2 (located in the gastrointestinal tract, also called GSHPx-GI, GPX-GI, and GI-GPx), like glutathione peroxidase 1 (GPX1, ubiquitous), reduces one molecule of hydrogen peroxide (H2O2) with two molecules of glutathione to yield one molecule of oxidized glutathione (glutathione disulfide, GSSG) and two molecules of water (Chu et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
8428933	Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI Chu, FF, Doroshow, JH, Esworthy, RS	J Biol Chem	1993