GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
R-HSA-3341277
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
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GPX2 (located in the gastrointestinal tract, also called GSHPx-GI, GPX-GI, and GI-GPx), like glutathione peroxidase 1 (GPX1, ubiquitous), reduces one molecule of hydrogen peroxide (H2O2) with two molecules of glutathione to yield one molecule of oxidized glutathione (glutathione disulfide, GSSG) and two molecules of water (Chu et al. 1998).

Literature References
PubMed ID Title Journal Year
8428933 Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI

Esworthy, RS, Chu, FF, Doroshow, JH

J Biol Chem 1993
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Catalyst Activity

glutathione peroxidase activity of GPX2 tetramer [cytosol]

Physical Entity
GPX2 tetramer [cytosol] (Homo sapiens)
Activity
glutathione peroxidase activity (GO:0004602)
Orthologous Events
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
Cross References
Rhea
Authored
May, B  (2013-05-09)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Kavdia, M  (2013-11-01)
Created
May, B  (2013-05-11)
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