Reactome | Btn-PC [cytosol]

Btn-PC [cytosol]

Stable Identifier

R-HSA-3323170

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

pyruvate carboxylase, Pyruvate carboxylase, mitochondrial precursor , Pyruvic carboxylase

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External Reference Information

External Reference

UniProt:P11498 PC

Gene Names

Chain

transit peptide:1-20, chain:21-1178

Reference Genes

BioGPS Gene:5091 PC

COSMIC (genes):PC PC

CTD Gene:5091 PC

dbSNP Gene:5091 PC

ENSEMBL:ENSG00000173599 PC

HGNC:8636 PC

KEGG:hsa:5091 PC

Monarch:5091 PC

NCBI Gene:5091 PC

OMIM:608786 PC

UCSC:P11498 PC

Reference Transcript

Other Identifiers

11722121_a_at

11745390_a_at

16740914

204476_PM_s_at

204476_s_at

3378534

3378536

3378542

3378543

3378544

3378545

3378546

3378547

3378548

3378549

3378550

3378551

3378552

3378553

3378554

3378555

3378556

3378557

3378559

3378560

3378561

3378562

3378564

3378567

3378569

3378571

3378572

3378573

3378574

3378575

3378576

3378577

3378581

3378585

3378586

3378587

3378588

3378589

3378590

3378591

38000_at

3966147

5091

7949719

84160_at

A_23_P161647

A_33_P3244347

GE58801

GO:0003824

GO:0004736

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005975

GO:0006090

GO:0006094

GO:0006629

GO:0006734

GO:0006739

GO:0009374

GO:0010629

GO:0016874

GO:0019074

GO:0019076

GO:0042802

GO:0043226

GO:0044794

GO:0046872

GO:0055086

HMNXSV003043901

ILMN_1671489

ILMN_1736689

ILMN_2340347

PH_hs_0005027

S72370_at

TC11001976.hg

g11761614_3p_a_at

Participates

as a component of

4x(Btn-PC:Mn2+) [cytosol] (Homo sapiens)

Other forms of this molecule

Btn-PC [mitochondrial matrix]

PC [cytosol]

Inferred To

PC [cytosol] (Canis familiaris)

Ghost homologue of Btn-PC [cytosol] (Xenopus tropicalis)

Btn-PC [cytosol] (Bos taurus)

Btn-PC [cytosol] (Caenorhabditis elegans)

Btn-PC [cytosol] (Danio rerio)

Btn-PC [cytosol] (Drosophila melanogaster)

Btn-PC [cytosol] (Mus musculus)

Btn-PC [cytosol] (Rattus norvegicus)

Btn-PC [cytosol] (Saccharomyces cerevisiae)

Btn-PC [cytosol] (Schizosaccharomyces pombe)

Btn-PC [cytosol] (Sus scrofa)

Modified Residues

Name

N6-biotinyl-L-lysine at 1144

Coordinate

1144

PsiMod Name

N6-biotinyl-L-lysine [MOD:00126]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine.

Cross References

RefSeq

XP_016873358.1, NP_071504.2, XP_005274089.1, XP_005274088.1, XP_016873357.1, NP_000911.2, XP_016873360.1, XP_016873359.1, XP_016873361.1, XP_006718641.1, XP_011543388.1, NP_001035806.1

Guide to Pharmacology - Targets

1262

OpenTargets

ENSG00000173599

ENSEMBL

ENSP00000377530, ENSP00000498406, ENST00000529047, ENSP00000498994, ENSP00000498302, ENSP00000434192, ENST00000393960, ENST00000524491, ENST00000651036, ENSP00000377527, ENST00000652125, ENST00000393958, ENSP00000435905, ENSP00000377532, ENST00000651854, ENST00000393955

HPA

ENSG00000173599-PC

PRO

P11498

Pharos - Targets

P11498

Orphanet

GlyGen

P11498

HMDB Protein

HMDBP00019

PDB

7WTD, 3BG9, 8J7O, 7WTE, 3BG3, 8HWL, 7WTC, 7WTB, 7WTA

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48163 ME1	2	p-S336-ME1 [cytosol] (R-HSA-9861606) ME1 [cytosol] (R-HSA-400119)	0.668	14
UniProt:Q9Y3F4 STRAP	1	STRAP [cytosol] (R-HSA-2127556)	0.527	3
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:O95861 BPNT1	1	BPNT1 [cytosol] (R-HSA-176573)	0.527	2