TXNRD2 catalyzes the reduction of TXN2 by NADPH

Stable Identifier
R-HSA-3323050
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Thioredoxin reductase 2 (TXNRD2) in the mitochondrial matrix regenerates reduced thioredoxin (TXN) by reacting oxidized thioredoxin with NADPH (Gasdaska et al. 1999, Cao et al. 2007).

Literature References
PubMed ID Title Journal Year
17707404 Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state

Cao, Z, Bhella, D, Lindsay, JG

J. Mol. Biol. 2007
9923614 Cloning, sequencing and functional expression of a novel human thioredoxin reductase

Gasdaska, PY, Berggren, MM, Berry, MJ, Powis, G

FEBS Lett. 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thioredoxin-disulfide reductase activity of TXNRD2 dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created