TXNRD2 catalyzes the reduction of TXN2 by NADPH

Stable Identifier
R-HSA-3323050
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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TXNRD2 catalyzes the reduction of TXN2 by NADPH
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Thioredoxin reductase 2 (TXNRD2) in the mitochondrial matrix regenerates reduced thioredoxin (TXN) by reacting oxidized thioredoxin with NADPH (Gasdaska et al. 1999, Cao et al. 2007).
Literature References
PubMed ID Title Journal Year
9923614 Cloning, sequencing and functional expression of a novel human thioredoxin reductase

Gasdaska, PY, Berggren, MM, Berry, MJ, Powis, G

FEBS Lett. 1999
17707404 Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state

Cao, Z, Bhella, D, Lindsay, JG

J. Mol. Biol. 2007
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Catalyst Activity

thioredoxin-disulfide reductase (NADPH) activity of TXNRD2 dimer [mitochondrial matrix]

Physical Entity
TXNRD2 dimer [mitochondrial matrix] (Homo sapiens)
Activity
thioredoxin-disulfide reductase (NADPH) activity (GO:0004791)
Orthologous Events
TXNRD2 catalyzes the reduction of TXN2 by NADPH (Bos taurus)
TXNRD2 catalyzes the reduction of TXN2 by NADPH (Caenorhabditis elegans)
TXNRD2 catalyzes the reduction of TXN2 by NADPH (Danio rerio)
TXNRD2 catalyzes the reduction of TXN2 by NADPH (Gallus gallus)
TXNRD2 catalyzes the reduction of TXN2 by NADPH (Mus musculus)
TXNRD2 catalyzes the reduction of TXN2 by NADPH (Rattus norvegicus)
Authored
May, B  (2013-05-05)
Reviewed
Kavdia, M  (2013-11-01)
Created
May, B  (2013-05-09)
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