Peroxiredoxin 3 (PRDX3) and PRDX5 in the mitochondrial matrix reduce hydrogen peroxide (H2O2) with thioredoxin to yield oxidized thioredoxin and water (Yamashita et al. 1999, Knoops et al. 1999, Cao et al. 2007, Nagy et al. 2011). Reduced PRDX5 is a monomer (Declercq et al. 2001) and oxidized PRDX5 is a dimer (Evrard et al. 2004) therefore the enzyme may cycle between states.
Declercq, JP, Evrard, C, Clippe, A, Stricht, DV, Bernard, A, Knoops, B
Evrard, C, Capron, A, Marchand, C, Clippe, A, Wattiez, R, Soumillion, P, Knoops, B, Declercq, JP
Cao, Z, Bhella, D, Lindsay, JG
Knoops, B, Clippe, A, Bogard, C, Arsalane, K, Wattiez, R, Hermans, C, Duconseille, E, Falmagne, P, Bernard, A
Nagy, P, Karton, A, Betz, A, Peskin, AV, Pace, P, O'Reilly, RJ, Hampton, MB, Radom, L, Winterbourn, CC
Yamashita, H, Avraham, S, Jiang, S, London, R, Van Veldhoven, PP, Subramani, S, Rogers, RA, Avraham, H
thioredoxin peroxidase activity of PRDX3,5 [mitochondrial matrix]
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