PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

Stable Identifier
R-HSA-3322995
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Peroxiredoxin 3 (PRDX3) and PRDX5 in the mitochondrial matrix reduce hydrogen peroxide (H2O2) with thioredoxin to yield oxidized thioredoxin and water (Yamashita et al. 1999, Knoops et al. 1999, Cao et al. 2007, Nagy et al. 2011). Reduced PRDX5 is a monomer (Declercq et al. 2001) and oxidized PRDX5 is a dimer (Evrard et al. 2004) therefore the enzyme may cycle between states.

Literature References
PubMed ID Title Journal Year
11518528 Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution

Declercq, JP, Evrard, C, Clippe, A, Stricht, DV, Bernard, A, Knoops, B

J. Mol. Biol. 2001
15046979 Crystal structure of a dimeric oxidized form of human peroxiredoxin 5

Evrard, C, Capron, A, Marchand, C, Clippe, A, Wattiez, R, Soumillion, P, Knoops, B, Declercq, JP

J. Mol. Biol. 2004
17707404 Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state

Cao, Z, Bhella, D, Lindsay, JG

J. Mol. Biol. 2007
10521424 Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family

Knoops, B, Clippe, A, Bogard, C, Arsalane, K, Wattiez, R, Hermans, C, Duconseille, E, Falmagne, P, Bernard, A

J. Biol. Chem. 1999
21385867 Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study

Nagy, P, Karton, A, Betz, A, Peskin, AV, Pace, P, O'Reilly, RJ, Hampton, MB, Radom, L, Winterbourn, CC

J. Biol. Chem. 2011
10514471 Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro

Yamashita, H, Avraham, S, Jiang, S, London, R, Van Veldhoven, PP, Subramani, S, Rogers, RA, Avraham, H

J. Biol. Chem. 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thioredoxin peroxidase activity of PRDX3,5 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created