Reactome | PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

Stable Identifier

R-HSA-3322995

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

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Peroxiredoxin 3 (PRDX3) and PRDX5 in the mitochondrial matrix reduce hydrogen peroxide (H2O2) with thioredoxin to yield oxidized thioredoxin and water (Yamashita et al. 1999, Knoops et al. 1999, Cao et al. 2007, Nagy et al. 2011). Reduced PRDX5 is a monomer (Declercq et al. 2001) and oxidized PRDX5 is a dimer (Evrard et al. 2004) therefore the enzyme may cycle between states.

Literature References

PubMed ID	Title	Journal	Year
15046979	Crystal structure of a dimeric oxidized form of human peroxiredoxin 5 Capron, A, Wattiez, R, Marchand, C, Evrard, C, Soumillion, P, Knoops, B, Clippe, A, Declercq, JP	J. Mol. Biol.	2004
11518528	Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution Clippe, A, Declercq, JP, Bernard, A, Evrard, C, Knoops, B, Stricht, DV	J. Mol. Biol.	2001
17707404	Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state Bhella, D, Lindsay, JG, Cao, Z	J. Mol. Biol.	2007
10521424	Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family Clippe, A, Arsalane, K, Bogard, C, Bernard, A, Wattiez, R, Knoops, B, Falmagne, P, Duconseille, E, Hermans, C	J. Biol. Chem.	1999
21385867	Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study Radom, L, Hampton, MB, O'Reilly, RJ, Karton, A, Nagy, P, Pace, P, Peskin, AV, Betz, A, Winterbourn, CC	J. Biol. Chem.	2011
10514471	Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro Subramani, S, London, R, Avraham, S, Rogers, RA, Van Veldhoven, PP, Avraham, H, Yamashita, H, Jiang, S	J. Biol. Chem.	1999