After ubiquitinating TLE, XIAP presumably dissociates. The model proposed by Hanson et al suggests the existence of an as-yet unidentified deubiquitinase that removes the ubiquitin from TLE to allow it to rebind to TCF/LEF.
Beauchamp, RD, Freeman, TJ, Wallace, HA, Hanson, AJ, Lee, E, Lee, LA
© 2023 Reactome