After ubiquitinating TLE, XIAP presumably dissociates. The model proposed by Hanson et al suggests the existence of an as-yet unidentified deubiquitinase that removes the ubiquitin from TLE to allow it to rebind to TCF/LEF.
Hanson, AJ, Wallace, HA, Freeman, TJ, Beauchamp, RD, Lee, LA, Lee, E
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