Reactome | XIAP dissociates from ub-TLE

XIAP dissociates from ub-TLE

Stable Identifier

R-HSA-3322434

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After ubiquitinating TLE, XIAP presumably dissociates. The model proposed by Hanson et al suggests the existence of an as-yet unidentified deubiquitinase that removes the ubiquitin from TLE to allow it to rebind to TCF/LEF.

Literature References

PubMed ID	Title	Journal	Year
22304967	XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling Hanson, AJ, Wallace, HA, Freeman, TJ, Beauchamp, RD, Lee, LA, Lee, E	Mol. Cell	2012