XIAP dissociates from ub-TLE

Stable Identifier
R-HSA-3322434
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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After ubiquitinating TLE, XIAP presumably dissociates. The model proposed by Hanson et al suggests the existence of an as-yet unidentified deubiquitinase that removes the ubiquitin from TLE to allow it to rebind to TCF/LEF.

Literature References
PubMed ID Title Journal Year
22304967 XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling

Hanson, AJ, Wallace, HA, Freeman, TJ, Beauchamp, RD, Lee, LA, Lee, E

Mol. Cell 2012
Participants
Participant Of
Orthologous Events
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Reviewed
Created