Reactome | Beta-catenin recruits CBP/p300

Beta-catenin recruits CBP/p300

Stable Identifier

R-HSA-3322427

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CBP (CREB-binding protein) and the closely related p300 are histone acetyltransferases that are recruited to WNT-responsive promoters through interactions with the C-terminal half of beta-catenin (Hecht et al, 2000; Takemura and Moon, 2000; Sun et al, 2000). Although recruitment is WNT-signaling dependent and results in activation of several WNT target genes, the precise role of CBP and p300 is not yet clear. In Drosophila, recruitment of CBP can affect the acetylation of histones H3 and H4 up to 30kb away from WREs, possibly aided by the DNA bending induced by TCFs (Parker et al, 2008); in other instances, the intrinsic HAT activity has been shown to acetylate beta-catenin (Levy et al, 2004; Wolf et al, 2002), or to be dispensable for the transcriptional activation activity of CBP/p300 at WREs (Hecht et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
10775268	The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates Kemler, R, van Roy, F, Hecht, A, Vleminckx, K, Stemmler, MP	EMBO J.	2000
18160704	Wingless signaling induces widespread chromatin remodeling of target loci Chang, JL, Ni, YY, Cadigan, KM, Parker, DS, Li, J	Mol. Cell. Biol.	2008
11973335	Acetylation of beta-catenin by CREB-binding protein (CBP) Wolf, D, Kouzarides, T, Calvet, JP, Rodova, M, Miska, EA	J. Biol. Chem.	2002
15060161	Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction Neuveut, C, Wei, Y, Wu, Y, Labalette, C, Buendia, MA, Lévy, L, Renard, CA	Mol. Cell. Biol.	2004
10769018	The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression Takemaru, KI, Moon, RT	J. Cell Biol.	2000
11050151	Regulation of beta -catenin transformation by the p300 transcriptional coactivator Hottiger, MO, Kolligs, FT, Fearon, ER, Sun, Y, Nabel, GJ, Mosavin, R	Proc. Natl. Acad. Sci. U.S.A.	2000