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XIAP [nucleoplasm]
Stable Identifier
R-HSA-3322366
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
API3, BIRC4, IAP3
Locations in the PathwayBrowser for interactor UniProt:P46531 NOTCH1
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
XIAP binds TLE (Homo sapiens)
XIAP [nucleoplasm] (Homo sapiens)
XIAP dissociates from ub-TLE (Homo sapiens)
XIAP [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98170 XIAP
Gene Names
XIAP, API3, BIRC4, IAP3
Chain
chain:1-497
Reference Genes
BioGPS Gene:331 XIAP
COSMIC (genes):XIAP XIAP
CTD Gene:331 XIAP
dbSNP Gene:331 XIAP
ENSEMBL:ENSG00000101966 XIAP
ENSEMBL_homo_sapiens_GENE:ENSG00000101966.14 XIAP
HGNC:592 XIAP
KEGG Gene (Homo sapiens):331 XIAP
Monarch:331 XIAP
NCBI Gene:331 XIAP
OMIM:300079 XIAP
UCSC:P98170 XIAP
Reference Transcript
RefSeq:NM_001204401.1 XIAP
RefSeq:NM_001167.3 XIAP
RefSeq:XM_006724754.2 XIAP
RefSeq:XM_011531329.2 XIAP
Other Identifiers
11725698_x_at
11725699_at
11725700_s_at
11755086_x_at
11757039_a_at
17106723
206536_PM_s_at
206536_s_at
225858_3p_s_at
225858_PM_s_at
225858_s_at
225859_PM_at
225859_at
228363_PM_at
228363_at
235222_3p_x_at
235222_PM_x_at
235222_x_at
243026_PM_x_at
243026_x_at
3263489
331
3989687
3989688
3989689
3989690
3989696
3989697
3989698
3989699
3989700
3989701
3989703
3989704
3989705
3989706
3989707
3989708
51813_at
69767_at
78549_at
8169742
92143_r_at
A_14_P118310
A_23_P22460
A_33_P3246990
GO:0002376
GO:0003824
GO:0004842
GO:0004869
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006915
GO:0006954
GO:0006974
GO:0010804
GO:0012501
GO:0016055
GO:0016740
GO:0023052
GO:0030414
GO:0030510
GO:0031398
GO:0032481
GO:0036211
GO:0042127
GO:0042742
GO:0042802
GO:0042981
GO:0043027
GO:0043066
GO:0043123
GO:0043154
GO:0043226
GO:0045088
GO:0046330
GO:0046872
GO:0050727
GO:0051402
GO:0051604
GO:0051726
GO:0055065
GO:0055070
GO:0060785
GO:0061135
GO:0061630
GO:0070424
GO:0070427
GO:0070431
GO:0070534
GO:0090263
GO:0097340
GO:0098542
GO:0098772
GO:0120283
GO:0140096
GO:1902530
HMNXSV003007420
Hs.201262.0.S1_3p_x_at
Hs.201262.1.S1_3p_a_at
Hs.321435.1.A1_3p_a_at
Hs.321435.1.A1_3p_at
Hs.5367.0.A1_3p_at
Hs2Affx.1.433.S1_3p_x_at
ILMN_1815361
PH_hs_0023989
PH_hs_0041066
TC0X000604.hg
TC0X001858.hg
g1016687_3p_a_at
Participates
as an output of
XIAP dissociates from ub-TLE (Homo sapiens)
as a component of
ub-TLE:XIAP [nucleoplasm] (Homo sapiens)
TLE:XIAP [nucleoplasm] (Homo sapiens)
as an input of
XIAP binds TLE (Homo sapiens)
Other forms of this molecule
K48pUb-XIAP [cytosol]
XIAP [cytosol]
Inferred To
IAP3 [nucleoplasm]
(Gallus gallus)
xiap [nucleoplasm]
(Danio rerio)
XIAP [nucleoplasm]
(Bos taurus)
XIAP [nucleoplasm]
(Drosophila melanogaster)
XIAP [nucleoplasm]
(Mus musculus)
XIAP [nucleoplasm]
(Rattus norvegicus)
XIAP [nucleoplasm]
(Sus scrofa)
XIAP [nucleoplasm]
(Xenopus tropicalis)
BIRC4 [nucleoplasm]
(Canis familiaris)
Homologues of XIAP [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
XP_006724817.1
,
NP_001191330.1
,
NP_001158.2
,
XP_011529631.1
Guide to Pharmacology - Targets
2790
OpenTargets
ENSG00000101966
ZINC - Substances
XIAP_HUMAN
ZINC - Biogenic
XIAP_HUMAN
ZINC target
P98170
PRO
P98170
PDB
4WVS
,
4J45
,
1TFQ
,
5C0K
,
2ECG
,
5C7C
,
4J44
,
1F9X
,
4IC3
,
5OQW
,
2VSL
,
3UW5
,
5C7B
,
5C3K
,
4J3Y
,
2POP
,
5C7A
,
5C83
,
3UW4
,
2JK7
,
6GJW
,
5C3H
,
4KJV
,
5C84
,
1NW9
,
4KJU
,
2POI
,
3EYL
,
3CM7
,
4J48
,
8AZA
,
6EY2
,
5O6T
,
2OPZ
,
5M6E
,
2OPY
,
6QCI
,
3CLX
,
3CM2
,
1I51
,
8GH7
,
5M6F
,
3G76
,
1KMC
,
4MTZ
,
1I4O
,
1G3F
,
5M6H
,
4IC2
,
8W59
,
2KNA
,
1G73
,
4OXC
,
5M6L
,
4EC4
,
1C9Q
,
5M6M
,
8W5A
,
4WVU
,
4J47
,
4HY0
,
4KMP
,
4J46
,
2QRA
,
5C0L
,
4WVT
,
5C7D
,
1I3O
,
3HL5
,
1TFT
ZINC - Investigational
XIAP_HUMAN
IntEnz
2.3.2.27
GeneCards
P98170
HPA
ENSG00000101966-XIAP
Ensembl
ENST00000355640
,
ENSP00000405529
,
ENSG00000101966
,
ENSP00000360242
,
ENST00000371199
,
ENST00000422098
,
ENSP00000347858
Pharos - Targets
P98170
Orphanet
16830
ZINC - Predictions - Purchasable
XIAP_HUMAN
Interactors (68)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55211 CASP9
5
p-S196-CASP9(1-416) [cytosol]
(R-HSA-198636)
p-T412-CASP9(1-416) [cytosol]
(R-HSA-9627087)
CASP9(331-416) [cytosol]
(R-HSA-141639)
CASP9(?-315) [cytosol]
(R-HSA-141638)
CASP9(1-416) [cytosol]
(R-HSA-57033)
0.97
25
UniProt:O43464 HTRA2
1
HTRA2 [mitochondrial intermembrane space]
(R-HSA-56655)
0.959
23
UniProt:O43353 RIPK2
2
RIPK2 [cytosol]
(R-HSA-168402)
Ub-209-RIPK2 [cytosol]
(R-HSA-706483)
0.951
22
UniProt:Q9NR28 DIABLO
2
DIABLO [mitochondrial intermembrane space]
(R-HSA-64637)
DIABLO [cytosol]
(R-HSA-114298)
0.933
11
UniProt:P42574 CASP3
5
CASP3(1-277) [cytosol]
(R-HSA-57021)
CASP3(29-175) [nucleoplasm]
(R-HSA-211194)
CASP3(176-277) [nucleoplasm]
(R-HSA-211203)
CASP3(29-175) [cytosol]
(R-HSA-141644)
CASP3(176-277) [cytosol]
(R-HSA-141646)
0.872
7
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.846
6
UniProt:P55210 CASP7
5
CASP7(24-198) [nucleoplasm]
(R-HSA-351927)
CASP7(207-303) [nucleoplasm]
(R-HSA-351924)
CASP7(2-303) [cytosol]
(R-HSA-57029)
CASP7(24-198) [cytosol]
(R-HSA-141641)
CASP7(207-303) [cytosol]
(R-HSA-141642)
0.836
6
UniProt:P40937 RFC5
1
RFC5 [nucleoplasm]
(R-HSA-68427)
0.83
9
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.785
5
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.782
6
UniProt:Q17RB8 LONRF1
1
LONRF1 [cytosol]
(R-HSA-8850905)
0.781
7
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.781
7
UniProt:A5D8V6 VPS37C
1
VPS37C [endosome membrane]
(R-HSA-184438)
0.781
7
UniProt:P83105 HTRA4
0.764
11
UniProt:P83110-1 HTRA3
0.749
7
UniProt:Q15750 TAB1
6
TAB1(445-504) [cytosol]
(R-HSA-9729691)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1 [cytosol]
(R-HSA-167923)
0.748
5
UniProt:P63167 DYNLL1
6
DYNLL1 [ciliary tip]
(R-HSA-5625335)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
0.725
4
UniProt:Q96HA8 NTAQ1
0.712
4
UniProt:P83110 HTRA3
0.705
8
UniProt:O43447 PPIH
2
PPIH [nucleoplasm]
(R-HSA-6806776)
PPIH [cytosol]
(R-HSA-9728791)
0.696
5
UniProt:Q9NR28-1 DIABLO
0.676
4
UniProt:Q13404 UBE2V1
1
UBE2V1 [cytosol]
(R-HSA-205753)
0.667
3
UniProt:Q9HC98 NEK6
2
NEK6 [cytosol]
(R-HSA-2530596)
p-S206-NEK6 [cytosol]
(R-HSA-2984253)
0.666
4
UniProt:Q9Y2D8 ADIP
0.666
4
UniProt:P19447 ERCC3
1
ERCC3 [nucleoplasm]
(R-HSA-67439)
0.666
4
UniProt:P83110-2 HTRA3
0.661
6
ChEBI:47924 N,N'-(HEXANE-1,6-DIYL)BIS(1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINAMIDE)
0.618
4
ChEBI:47922 METHYL 1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINATE
0.618
6
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.602
4
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.602
3
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.591
3
UniProt:Q96CN9 GCC1
1
GCC1 [cytosol]
(R-HSA-6813877)
0.556
3
UniProt:P07686 HEXB
11
HEXB S62L [lysosomal lumen]
(R-HSA-3700901)
HEXB R284* [lysosomal lumen]
(R-HSA-3700930)
HEXB M26Cfs*5 [lysosomal lumen]
(R-HSA-3700843)
HEXB I322Kfs*5 [lysosomal lumen]
(R-HSA-3700889)
HEXB(315-556) [extracellular region]
(R-HSA-6806188)
HEXB(122-311) [extracellular region]
(R-HSA-6806190)
HEXB(315-556) [azurophil granule lumen]
(R-HSA-6799134)
HEXB(122-311) [azurophil granule lumen]
(R-HSA-6799125)
HEXB(316-556) [lysosomal lumen]
(R-HSA-1605605)
HEXB(122-311) [lysosomal lumen]
(R-HSA-1605777)
HEXB(50-107) [lysosomal lumen]
(R-HSA-9842398)
0.556
3
UniProt:Q4G0R1 Q4G0R1
0.556
3
UniProt:A0A087WZT3 A0A087WZT3
0.556
3
UniProt:P32502
1
GCD7 [cytosol]
(R-SCE-72519)
0.556
3
UniProt:Q06455-2 RUNX1T1
0.556
3
UniProt:Q01976
1
NUDT5 [cytosol]
(R-SCE-2393933)
0.556
3
UniProt:Q3E793 BOL1
0.556
3
UniProt:Q9Y3E2 BOLA1
0.556
3
UniProt:Q8N3J5 PPM1K
2
H139Hfs13* PPM1K [mitochondrial matrix]
(R-HSA-9912515)
PPM1K [mitochondrial matrix]
(R-HSA-5693145)
0.556
3
UniProt:P38340 NTM1
0.556
3
UniProt:Q92851-4 CASP10
0.556
3
UniProt:Q5W5X9-3 TTC23
0.556
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.556
3
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.556
3
UniProt:Q92851 CASP10
4
CASP10(220-415) [cytosol]
(R-HSA-933458)
CASP10(1-219) [cytosol]
(R-HSA-933454)
CASP10(416-521) [cytosol]
(R-HSA-933455)
CASP10(1-521) [cytosol]
(R-HSA-933453)
0.556
3
UniProt:P57078 RIPK4
0.544
2
UniProt:O75173 ADAMTS4
4
ADAMTS4 [extracellular region]
(R-HSA-2533998)
ADAMTS4 [endoplasmic reticulum lumen]
(R-HSA-5173253)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(R-HSA-5172994)
O-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(R-HSA-5173144)
0.527
3
UniProt:Q9Y240 CLC11
0.527
2
UniProt:Q96P09 BIRC8
0.527
3
UniProt:Q96IK5 GMCL1
0.527
2
UniProt:Q5T6F0 DCA12
0.527
3
UniProt:P61077 UBE2D3
3
UBE2D3 [nucleoplasm]
(R-HSA-205341)
UBE2D3 [cytosol]
(R-HSA-934630)
Ub-C85-UBE2D3 [cytosol]
(R-HSA-8864191)
0.527
2
UniProt:Q9HC29 NOD2
1
NOD2 [cytosol]
(R-HSA-168411)
0.527
2
UniProt:Q96CA5 BIRC7
1
BIRC7 [cytosol]
(R-HSA-50855)
0.527
3
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.527
3
UniProt:Q99623 PHB2
1
PHB2 [mitochondrial inner membrane]
(R-HSA-8953721)
0.527
3
UniProt:O75325 LRRN2
0.527
2
UniProt:P62837 UBE2D2
4
Ub-C85-UBE2D2 [nucleoplasm]
(R-HSA-8864153)
UBE2D2 [nucleoplasm]
(R-HSA-8852067)
UBE2D2 [cytosol]
(R-HSA-934628)
Ub-C85-UBE2D2 [cytosol]
(R-HSA-8864214)
0.527
2
UniProt:P61088 UBE2N
5
Ub-C87-UBE2N [nucleoplasm]
(R-HSA-8943013)
K63polyUb-C87-UBE2N [nucleoplasm]
(R-HSA-6790511)
UBE2N [nucleoplasm]
(R-HSA-5682541)
Ub-C87-UBE2N [cytosol]
(R-HSA-8864210)
UBE2N [cytosol]
(R-HSA-206072)
0.527
2
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.524
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.519
2
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.508
2
UniProt:O14618 CCS
2
CCS [mitochondrial intermembrane space]
(R-HSA-3777060)
CCS [cytosol]
(R-HSA-3299714)
0.499
2
UniProt:Q9JIQ3-PRO_0000021073 DIABLO
0.499
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.488
2
UniProt:P50570 DNM2
5
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [plasma membrane]
(R-HSA-2984201)
0.488
2
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