Autoglucosylation of GYG2 complexed with GYS2-b

Stable Identifier
R-HSA-3322019
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
8 UDP-glucose + GYG2 => 8 UDP + oligoGlc-GYG2 (GYS2-b)
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Autoglucosylation of GYG2 complexed with GYS2-b
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Glycogenin 2 (GYG2) catalyzes its autoglycosylation reaction with UDP-glucose to form oligo (1,4)-alpha-D-glucosyl GYG2 (Mu et al. 1997). The oligosaccharide is annotated here as containing four glucose residues. Glycogenin occurs as a homodimer complexed with two molecules of glycogen synthase 1 (GYS2), here in a phosphorylated (b) form (Roach et al. 2012).

Literature References
PubMed ID Title Journal Year
9346895 Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis.

Mu, J, Skurat, AV, Roach, PJ

J Biol Chem 1997
22248338 Glycogen and its metabolism: some new developments and old themes

Roach, PJ, DePaoli-Roach, AA, Hurley, TD, Tagliabracci, VS

Biochem. J. 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glycogenin glucosyltransferase activity of GYG2:GYS2-b tetramer [cytosol]
Physical Entity
GYG2:GYS2-b tetramer [cytosol]
Activity
glycogenin glucosyltransferase activity (0008466)
Orthologous Events
Autoglucosylation of GYG2 complexed with GYS2-b (Caenorhabditis elegans)
Autoglucosylation of GYG2 complexed with GYS2-b (Canis familiaris)
Autoglucosylation of GYG2 complexed with GYS2-b (Dictyostelium discoideum)
Autoglucosylation of GYG2 complexed with GYS2-b (Gallus gallus)
Autoglucosylation of GYG2 complexed with GYS2-b (Saccharomyces cerevisiae)
Autoglucosylation of GYG2 complexed with GYS2-b (Sus scrofa)
Reviewed
Jassal, B  (2013-07-26)
Created
D'Eustachio, P  (2013-05-03)
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