Reactome | Autoglucosylation of GYG2 complexed with GYS2-b

Autoglucosylation of GYG2 complexed with GYS2-b

Stable Identifier

R-HSA-3322019

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

L-tyrosyl-(glycogenin) + UDP-alpha-D-glucose => alpha-D-glucosyl-L-tyrosyl-(glycogenin) + UDP + H(+), 8 UDP-glucose + GYG2 => 8 UDP + oligoGlc-GYG2 (GYS2-b)

ReviewStatus

4/5

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Autoglucosylation of GYG2 complexed with GYS2-b

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Glycogenin 2 (GYG2) catalyzes its autoglycosylation reaction with UDP-glucose to form oligo (1,4)-alpha-D-glucosyl GYG2 (Mu et al. 1997). The oligosaccharide is annotated here as containing four glucose residues. Glycogenin occurs as a homodimer complexed with two molecules of glycogen synthase 1 (GYS2), here in a phosphorylated (b) form (Roach et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22248338	Glycogen and its metabolism: some new developments and old themes Roach, PJ, DePaoli-Roach, AA, Hurley, TD, Tagliabracci, VS	Biochem. J.	2012
9346895	Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis. Mu, J, Skurat, AV, Roach, PJ	J Biol Chem	1997