Reactome | GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a

GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a

Stable Identifier

R-HSA-3322016

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

poly((1,4)-alpha-D-glucosyl) glycogenin2 => glycogen-glycogenin 2 (GYS2-a)

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic glycogen branching enzyme (GBE1) associated with glycogen granules transfers terminal alpha(1,4) glucose blocks to form alpha(1,6) branches on growing glycogen molecules formed on glycogenin 2 (GYG2) complexed with unphosphorylated glycogen synthase 2 (GYS2-a) (Bao et al. 1996; Roach et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22248338	Glycogen and its metabolism: some new developments and old themes Roach, PJ, DePaoli-Roach, AA, Hurley, TD, Tagliabracci, VS	Biochem. J.	2012
8613547	Hepatic and neuromuscular forms of glycogen storage disease type IV caused by mutations in the same glycogen-branching enzyme gene. Bao, Y, Kishnani, P, Wu, JY, Chen, Y-T	J Clin Invest	1996