Autoglucosylation of GYG2 complexed with GYS2-a

Stable Identifier
R-HSA-3322014
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
8 UDP-glucose + GYG2 => 8 UDP + oligoGlc-GYG2 (GYS2-a)
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glycogenin 2 (GYG2) catalyzes its autoglycosylation reaction with UDP-glucose to form oligo (1,4)-alpha-D-glucosyl GYG2 (Mu et al. 1997). The oligosaccharide is annotated here as containing four glucose residues. Glycogenin occurs as a homodimer complexed with two molecules of glycogen synthase 1 (GYS2), here in a unphosphorylated (a) form (Roach et al. 2012).

Literature References
PubMed ID Title Journal Year
22248338 Glycogen and its metabolism: some new developments and old themes

Hurley, TD, Roach, PJ, Tagliabracci, VS, DePaoli-Roach, AA

Biochem. J. 2012
9346895 Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis.

Mu, J, Roach, PJ, Skurat, AV

J Biol Chem 1997
Participants
Participates
Catalyst Activity

glycogenin glucosyltransferase activity of GYG2:GYS2-a tetramer [cytosol]

Orthologous Events
Reviewed
Created
Cite Us!