Autoglucosylation of GYG2 complexed with GYS2-a

Stable Identifier
R-HSA-3322014
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
8 UDP-glucose + GYG2 => 8 UDP + oligoGlc-GYG2 (GYS2-a)
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Glycogenin 2 (GYG2) catalyzes its autoglycosylation reaction with UDP-glucose to form oligo (1,4)-alpha-D-glucosyl GYG2 (Mu et al. 1997). The oligosaccharide is annotated here as containing four glucose residues. Glycogenin occurs as a homodimer complexed with two molecules of glycogen synthase 1 (GYS2), here in a unphosphorylated (a) form (Roach et al. 2012).

Literature References
PubMed ID Title Journal Year
9346895 Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis.

Mu, J, Skurat, AV, Roach, PJ

J Biol Chem 1997
22248338 Glycogen and its metabolism: some new developments and old themes

Roach, PJ, DePaoli-Roach, AA, Hurley, TD, Tagliabracci, VS

Biochem. J. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycogenin glucosyltransferase activity of GYG2:GYS2-a tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created