Reactome | GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2

GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2

Stable Identifier

R-HSA-3322009

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin2 => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin2 (GYS2-a)

ReviewStatus

5/5

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GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2

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Unphosphorylated glycogen synthase 2 (GYS2-a) complexed with oligo-D-glucose-GYG2 catalyzes the polyglucosylation of the latter. (Here the addition of four glucose residues is annotated.) (Orho et al. 1998; Roach et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
9691087	Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0 Aynsley-Green, A, Orho, M, Gannon, MC, Nuttall, FQ, Blumel, P, Bosshard, NU, Groop, LC, Buist, NR, Gitzelmann, R	J Clin Invest	1998
22248338	Glycogen and its metabolism: some new developments and old themes Hurley, TD, Roach, PJ, Tagliabracci, VS, DePaoli-Roach, AA	Biochem. J.	2012