GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2

Stable Identifier
R-HSA-3322009
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin2 => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin2 (GYS2-a)
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Unphosphorylated glycogen synthase 2 (GYS2-a) complexed with oligo-D-glucose-GYG2 catalyzes the polyglucosylation of the latter. (Here the addition of four glucose residues is annotated.) (Orho et al. 1998; Roach et al. 2012).

Literature References
PubMed ID Title Journal Year
22248338 Glycogen and its metabolism: some new developments and old themes

Roach, PJ, DePaoli-Roach, AA, Hurley, TD, Tagliabracci, VS

Biochem. J. 2012
9691087 Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0

Orho, M, Bosshard, NU, Buist, NR, Gitzelmann, R, Aynsley-Green, A, Blumel, P, Gannon, MC, Nuttall, FQ, Groop, LC

J Clin Invest 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycogen (starch) synthase activity of oligoGlc-GYG2:GYS2-a tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created