Autoglucosylation of GYG1 complexed with GYS1-b

Stable Identifier
R-HSA-3322003
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
8 UDP-glucose + GYG1 => 8 UDP + oligoGlc-GYG1 (GYS1-b)
Locations in the PathwayBrowser
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Glycogenin 1 (GYG1) catalyzes its autoglycosylation reaction with UDP-glucose to form oligo (1,4)-alpha-D-glucosyl GYG1 (Moslemi et al. 2010). The oligosaccharide is annotated here as containing four glucose residues. Glycogenin occurs as a homodimer complexed with two molecules of glycogen synthase 1 (GYS1), here in a phosphorylated (b) form (Roach et al. 2012).

Literature References
PubMed ID Title Journal Year
22248338 Glycogen and its metabolism: some new developments and old themes

Roach, PJ, DePaoli-Roach, AA, Hurley, TD, Tagliabracci, VS

Biochem. J. 2012
20357282 Glycogenin-1 deficiency and inactivated priming of glycogen synthesis

Moslemi, AR, Lindberg, C, Nilsson, J, Tajsharghi, H, Andersson, B, Oldfors, A

N. Engl. J. Med. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycogenin glucosyltransferase activity of GYG1:GYS1-b tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created