Reactome | Autoglucosylation of GYG1 complexed with GYS1-b

Autoglucosylation of GYG1 complexed with GYS1-b

Stable Identifier

R-HSA-3322003

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

L-tyrosyl-(glycogenin) + UDP-alpha-D-glucose => alpha-D-glucosyl-L-tyrosyl-(glycogenin) + UDP + H(+), 8 UDP-glucose + GYG1 => 8 UDP + oligoGlc-GYG1 (GYS1-b)

ReviewStatus

4/5

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Autoglucosylation of GYG1 complexed with GYS1-b

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Glycogenin 1 (GYG1) catalyzes its autoglycosylation reaction with UDP-glucose to form oligo (1,4)-alpha-D-glucosyl GYG1 (Moslemi et al. 2010). The oligosaccharide is annotated here as containing four glucose residues. Glycogenin occurs as a homodimer complexed with two molecules of glycogen synthase 1 (GYS1), here in a phosphorylated (b) form (Roach et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
20357282	Glycogenin-1 deficiency and inactivated priming of glycogen synthesis Moslemi, AR, Lindberg, C, Nilsson, J, Tajsharghi, H, Andersson, B, Oldfors, A	N. Engl. J. Med.	2010
22248338	Glycogen and its metabolism: some new developments and old themes Roach, PJ, DePaoli-Roach, AA, Hurley, TD, Tagliabracci, VS	Biochem. J.	2012