GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1

Stable Identifier
R-HSA-3322001
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin2 => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin2 (GYS1-a)
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Unphosphorylated glycogen synthase 1 (GYS1-a) complexed with oligo-D-glucose-GYG1 catalyzes the polyglucosylation of the latter. (Here the addition of four glucose residues is annotated.) (Cameron et al. 2009; Roach et al. 2012).

Literature References
PubMed ID Title Journal Year
22248338 Glycogen and its metabolism: some new developments and old themes

Roach, PJ, DePaoli-Roach, AA, Hurley, TD, Tagliabracci, VS

Biochem. J. 2012
19699667 Identification of a novel mutation in GYS1 (muscle-specific glycogen synthase) resulting in sudden cardiac death, that is diagnosable from skin fibroblasts

Cameron, JM, Levandovskiy, V, Mackay, N, Utgikar, R, Ackerley, CA, Chiasson, D, Halliday, W, Raiman, J, Robinson, BH

Mol. Genet. Metab. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycogen (starch) synthase activity of oligoGlc-GYG1:GYS1-a tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created