Reactome | ATF2 acetylates histone H2B, H4

ATF2 acetylates histone H2B, H4

Stable Identifier

R-HSA-3318415

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ATF2 (activating transcription factor 2) is a basic leucine zipper (bZIP) protein and member of the activator protein-1 (AP-1) family (Wagner et al. 2001). The basic region of ATF2 binds DNA while the leucine zipper region allows dimerization with partners. ATF2 is a histone acetyltransferase (HAT), which specifically acetylates histones H2B and H4 in vitro. ATF2 is sequentially phosphorylated on threonine residues T69 and T71 by protein kinases ERK1/2 and p38 (van Dam et al. 1995, Livingstone et al. 1995, Ouwens et al. 2002, Baan et al. 2009). This phosphorylated form has increased HAT activity (Kawasaki et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10821277	ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation Kawasaki, H, Schiltz, L, Chiu, R, Itakura, K, Taira, K, Nakatani, Y, Yokoyama, KK	Nature	2000