Mn superoxide dismutase (SOD2) is located in the mitochondrial matrix where it catalyzes the reaction of two molecules of superoxide (O2-.) to form one molecule of oxygen (O2) and one molecule of hydrogen peroxide (H2O2). Data from mouse liver indicate that respiratory complex I leaks superoxide into the matrix and respiratory complex III leaks superoxide into both the matrix and the intermembrane space (Muller et al. 2004). Because of its negative charge superoxide is unable to cross membranes, however hydrogen peroxide, a product of SOD2, is released from mitochondria to the cytosol in proportion to the proton potential (inferred from rat heart mitochondria in Boveris et al. 2006, Korshunov et al. 1997).
Werber, MM, Greenstein, LA
Van Remmen, H, Muller, FL, Liu, Y
Starkov, AA, Korshunov, SS, Skulachev, VP
Hirano, K, Inoue, H, Ito, Y, Adachi, T, Sugiura, M
Nick, HS, O'Connor, D, Hsieh, Y, Silverman, DN, Hsu, JL, Tu, C
Seo, HG, Matsuda, Y, Deutsch, HF, Nakata, T, Kawata, S, Taniguchi, N, Ookawara, T, Tarui, S, Suzuki, K
Zaobornyj, T, Boveris, A, Valdez, LB, Bustamante, J
Nick, HS, Silverman, DN
superoxide dismutase activity of SOD2 tetramer [mitochondrial matrix]
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