Reactome | SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)

SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)

Stable Identifier

R-HSA-3299680

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

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SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)

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Mn superoxide dismutase (SOD2) is located in the mitochondrial matrix where it catalyzes the reaction of two molecules of superoxide (O2-.) to form one molecule of oxygen (O2) and one molecule of hydrogen peroxide (H2O2). Data from mouse liver indicate that respiratory complex I leaks superoxide into the matrix and respiratory complex III leaks superoxide into both the matrix and the intermembrane space (Muller et al. 2004). Because of its negative charge superoxide is unable to cross membranes, however hydrogen peroxide, a product of SOD2, is released from mitochondria to the cytosol in proportion to the proton potential (inferred from rat heart mitochondria in Boveris et al. 2006, Korshunov et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
15317809	Complex III releases superoxide to both sides of the inner mitochondrial membrane Muller, FL, Liu, Y, Van Remmen, H	J. Biol. Chem.	2004
2071038	Biochemical and stability properties of recombinant human MnSOD Werber, MM, Greenstein, LA	Free Radic. Res. Commun.	1991
9369223	High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria Korshunov, SS, Skulachev, VP, Starkov, AA	FEBS Lett.	1997
7021796	Purification of superoxide dismutases from human placenta using immunoadsorbent columns Sugiura, M, Adachi, T, Inoue, H, Ito, Y, Hirano, K	J. Pharmacobio-dyn.	1981
8663465	Catalytic properties of human manganese superoxide dismutase Hsu, JL, Hsieh, Y, Tu, C, O'Connor, D, Nick, HS, Silverman, DN	J. Biol. Chem.	1996
1668270	A three-step purification of manganese superoxide dismutase from human liver on both large and small scales Matsuda, Y, Suzuki, K, Ookawara, T, Nakata, T, Seo, HG, Kawata, S, Tarui, S, Deutsch, HF, Taniguchi, N	Protein Expr. Purif.	1991
16615992	Mitochondrial metabolic states regulate nitric oxide and hydrogen peroxide diffusion to the cytosol Boveris, A, Valdez, LB, Zaobornyj, T, Bustamante, J	Biochim. Biophys. Acta	2006
11912930	Catalytic pathway of manganese superoxide dismutase by direct observation of superoxide Silverman, DN, Nick, HS	Meth. Enzymol.	2002