Reactome | TAS2R10 [plasma membrane]

TAS2R10 [plasma membrane]

Stable Identifier

R-HSA-3299623

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 10, T2R10_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R10 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R10 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R10 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R10 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R10 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R10 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R10 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R10 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYW0 TAS2R10

Gene Names

TAS2R10

Chain

chain:1-307

Reference Genes

BioGPS Gene:50839 TAS2R10

COSMIC (genes):TAS2R10 TAS2R10

CTD Gene:50839 TAS2R10

dbSNP Gene:50839 TAS2R10

ENSEMBL:ENSG00000121318 TAS2R10

HGNC:14918 TAS2R10

KEGG:hsa:50839 TAS2R10

Monarch:50839 TAS2R10

NCBI Gene:50839 TAS2R10

OMIM:604791 TAS2R10

UCSC:Q9NYW0 TAS2R10

Reference Transcript

RefSeq:NM_023921.1 TAS2R10

Other Identifiers

11734392_at

16761495

221397_PM_at

221397_at

3444330

3444331

50839

7961249

ADDON002747.hg

A_23_P64888

GE525870

GO:0001580

GO:0004930

GO:0005515

GO:0005886

GO:0007186

GO:0008527

GO:0016020

GO:0033038

GO:0050877

GO:0050909

GO:0060089

HMNXSV003009632

ILMN_1811799

TC12001231.hg

g12965179_3p_at

Participates

as a member of

as a component of

TAS2R10:ligand [plasma membrane] (Homo sapiens)

Inferred To

t2r14 [plasma membrane] (Xenopus tropicalis)

t2r2 [plasma membrane] (Xenopus tropicalis)

TAS2R10 [plasma membrane] (Canis familiaris)

TAS2R10 [plasma membrane] (Sus scrofa)

Homologues of TAS2R10 [plasma membrane] (Danio rerio)

Homologues of TAS2R10 [plasma membrane] (Gallus gallus)

Homologues of TAS2R10 [plasma membrane] (Xenopus tropicalis)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

Tas2r106 [plasma membrane] (Mus musculus)

Tas2r106 [plasma membrane] (Rattus norvegicus)

tas2r200.1 [plasma membrane] (Danio rerio)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

T2R10C [plasma membrane] (Bos taurus)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

tas2r200.2 [plasma membrane] (Danio rerio)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_076410.1

Guide to Pharmacology - Targets

666

ENSEMBL

ENST00000576159, ENSG00000121318, ENST00000240619, ENSP00000240619, ENSG00000272805, ENSG00000277238, ENSP00000482990, ENST00000611256, ENSP00000461683

OpenTargets

ENSG00000121318

GeneCards

TAS2R10

HPA

ENSG00000121318-TAS2R10

PRO

Q9NYW0

Pharos - Targets

Q9NYW0

GlyGen

Q9NYW0

HMDB Protein

HMDBP08038