Reactome | TAS2R14 [plasma membrane]

TAS2R14 [plasma membrane]

Stable Identifier

R-HSA-3299618

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 14, T2R14_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R14 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R14 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R14 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R14 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R14 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R14 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R14 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R14 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYV8 TAS2R14

Gene Names

TAS2R14

Chain

chain:1-317

Reference Genes

BioGPS Gene:50840 TAS2R14

COSMIC (genes):TAS2R14 TAS2R14

CTD Gene:50840 TAS2R14

dbSNP Gene:50840 TAS2R14

ENSEMBL:ENSG00000212127 TAS2R14

ENSEMBL_homo_sapiens_GENE:ENSG00000212127.6 TAS2R14

ENSEMBL_homo_sapiens_GENE:ENSG00000261984.1 TAS2R14

ENSEMBL_homo_sapiens_GENE:ENSG00000276541.2 TAS2R14

HGNC:14920 TAS2R14

KEGG Gene (Homo sapiens):50840 TAS2R14

Monarch:50840 TAS2R14

NCBI Gene:50840 TAS2R14

OMIM:604790 TAS2R14

UCSC:Q9NYV8 TAS2R14

Reference Transcript

RefSeq:NM_023922.1 TAS2R14

Other Identifiers

106707243

11734579_at

16761502

221391_PM_at

221391_at

235762_PM_at

235762_at

3444433

3444435

3444437

3444438

3444439

48344_at

50840

7961279

ADDON002809.hg

A_23_P105495

GE80060

GO:0001580

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0008527

GO:0016020

GO:0023052

GO:0033038

GO:0050877

GO:0050896

GO:0050909

GO:0060089

HMNXSV003035592

Hs.91582.0.A1_3p_at

ILMN_1801349

PH_hs_0022210

TC12001235.hg

g12965181_3p_at

Participates

as a member of

as a component of

TAS2R14:ligand [plasma membrane] (Homo sapiens)

Inferred To

t2r14 [plasma membrane] (Xenopus tropicalis)

TAS2R14 [plasma membrane] (Bos taurus)

TAS2R14 [plasma membrane] (Sus scrofa)

t2r2 [plasma membrane] (Xenopus tropicalis)

Homologues of TAS2R14 [plasma membrane] (Danio rerio)

Homologues of TAS2R14 [plasma membrane] (Gallus gallus)

Homologues of TAS2R14 [plasma membrane] (Xenopus tropicalis)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

tas2r200.1 [plasma membrane] (Danio rerio)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

Tas2r140 [plasma membrane] (Mus musculus)

Tas2r140 [plasma membrane] (Rattus norvegicus)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

tas2r200.2 [plasma membrane] (Danio rerio)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_076411.1

Guide to Pharmacology - Targets

668

OpenTargets

ENSG00000212127

HPA

ENSG00000212127-TAS2R14

GeneCards

Q9NYV8

ZINC target

Q9NYV8

Ensembl

ENST00000575008, ENSG00000261984, ENSG00000212127, ENSP00000441949, ENSG00000276541, ENSP00000484251, ENSP00000458544, ENST00000537503, ENST00000614274

PRO

Q9NYV8

Pharos - Targets

Q9NYV8

PDB

8VY9, 8VY7