Reactome | TAS2R1 [plasma membrane]

TAS2R1 [plasma membrane]

Stable Identifier

R-HSA-3299611

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 1, TA2R1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R1 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYW7 TAS2R1

Gene Names

TAS2R1

Chain

chain:1-299

Reference Genes

BioGPS Gene:50834 TAS2R1

COSMIC (genes):TAS2R1 TAS2R1

CTD Gene:50834 TAS2R1

dbSNP Gene:50834 TAS2R1

ENSEMBL:ENSG00000169777 TAS2R1

HGNC:14909 TAS2R1

KEGG:hsa:50834 TAS2R1

Monarch:50834 TAS2R1

NCBI Gene:50834 TAS2R1

OMIM:604796 TAS2R1

UCSC:Q9NYW7 TAS2R1

Reference Transcript

RefSeq:NM_019599.2 TAS2R1

Other Identifiers

11732703_s_at

16994309

221324_PM_at

221324_at

2848124

2848125

2848126

2848130

2848135

50834

8110960

A_23_P402123

GE54985

GO:0001580

GO:0004930

GO:0005886

GO:0007186

GO:0008527

GO:0016020

GO:0033038

GO:0050877

GO:0050909

GO:0050912

GO:0060089

HMNXSV003019021

HMNXSV003048804

ILMN_1809098

PH_hs_0010070

PH_hs_0026972

TC05003420.hg

g9625042_3p_at

p13080

p33563

Participates

as a member of

as a component of

TAS2R1:ligand [plasma membrane] (Homo sapiens)

Inferred To

Tas2r119 [plasma membrane] (Mus musculus)

Tas2r119 [plasma membrane] (Rattus norvegicus)

tas2r200.1 [plasma membrane] (Danio rerio)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

TAS2R1 [plasma membrane] (Bos taurus)

TAS2R1 [plasma membrane] (Canis familiaris)

TAS2R1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_062545.1

Guide to Pharmacology - Targets

659

ENSEMBL

ENST00000382492, ENSG00000169777, ENSP00000371932

OpenTargets

ENSG00000169777

GeneCards

TAS2R1

HPA

ENSG00000169777-TAS2R1

PRO

Q9NYW7

Pharos - Targets

Q9NYW7

GlyGen

Q9NYW7