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TAS2R46 [plasma membrane]
Stable Identifier
R-HSA-3299610
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Taste receptor type 2 member 46, T2R46_HUMAN
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)
TAS2R:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan) [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R46:ligand [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R46:ligand [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R46:ligand [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R46:ligand [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R46:ligand [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T2Rs bind bitter-tasting compounds (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R46 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P59540 TAS2R46
Gene Names
TAS2R46
Chain
chain:1-309
Reference Genes
BioGPS Gene:259292 TAS2R46
COSMIC (genes):TAS2R46 TAS2R46
CTD Gene:259292 TAS2R46
dbSNP Gene:259292 TAS2R46
ENSEMBL:ENSG00000226761 TAS2R46
ENSEMBL:ENSG00000226761.3 TAS2R46
ENSEMBL:ENSG00000262525.3 TAS2R46
HGNC:18877 TAS2R46
KEGG Gene (Homo sapiens):259292 TAS2R46
Monarch:259292 TAS2R46
NCBI Gene:259292 TAS2R46
OMIM:612774 TAS2R46
UCSC:P59540 TAS2R46
Reference Transcript
RefSeq:NM_176887.2 TAS2R46
Other Identifiers
0002370592
11742393_at
11742394_x_at
16761521
259292
3444526
3444527
3444556
7961293
A_23_P376114
GE903053
GO:0001580
GO:0004930
GO:0005886
GO:0005929
GO:0007165
GO:0007186
GO:0016020
GO:0016021
GO:0023052
GO:0033038
GO:0042995
GO:0043226
GO:0050877
GO:0050896
GO:0050909
GO:0060089
GO:0060170
HMNXSV003049878
ILMN_1811572
TC12001240.hg
Participates
as a component of
TAS2R46:ligand [plasma membrane] (Homo sapiens)
as a member of
TAS2R (non-orphan) [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
Inferred To
Tas2r120 [plasma membrane]
(Mus musculus)
Tas2r120 [plasma membrane]
(Rattus norvegicus)
t2r6 [plasma membrane]
(Xenopus tropicalis)
t2r37 [plasma membrane]
(Xenopus tropicalis)
CAFA-T2R43 [plasma membrane]
(Canis familiaris)
t2r24 [plasma membrane]
(Xenopus tropicalis)
Homologues of TAS2R20 [plasma membrane]
(Danio rerio)
Homologues of TAS2R20 [plasma membrane]
(Gallus gallus)
Homologues of TAS2R20 [plasma membrane]
(Xenopus tropicalis)
TAS2R1b [plasma membrane]
(Danio rerio)
t2r49 [plasma membrane]
(Xenopus tropicalis)
t2r52 [plasma membrane]
(Xenopus tropicalis)
rab3gap2 [plasma membrane]
(Xenopus tropicalis)
t2r45 [plasma membrane]
(Xenopus tropicalis)
t2r5 [plasma membrane]
(Xenopus tropicalis)
LOC100492238 [plasma membrane]
(Xenopus tropicalis)
LOC101747503 [plasma membrane]
(Gallus gallus)
t2r50 [plasma membrane]
(Xenopus tropicalis)
LOC100486257 [plasma membrane]
(Xenopus tropicalis)
t2r38 [plasma membrane]
(Xenopus tropicalis)
tas2r1a [plasma membrane]
(Danio rerio)
LOC100154902 [plasma membrane]
(Sus scrofa)
t2r10 [plasma membrane]
(Xenopus tropicalis)
t2r20 [plasma membrane]
(Xenopus tropicalis)
t2r30 [plasma membrane]
(Xenopus tropicalis)
t2r36 [plasma membrane]
(Xenopus tropicalis)
LOC101731190 [plasma membrane]
(Xenopus tropicalis)
t2r4 [plasma membrane]
(Xenopus tropicalis)
t2r17 [plasma membrane]
(Xenopus tropicalis)
t2r41 [plasma membrane]
(Xenopus tropicalis)
LOC100492564 [plasma membrane]
(Xenopus tropicalis)
tas2r4 [plasma membrane]
(Xenopus tropicalis)
LOC782957 [plasma membrane]
(Bos taurus)
t2r34 [plasma membrane]
(Xenopus tropicalis)
LOC116407540 [plasma membrane]
(Xenopus tropicalis)
Tas2r136 [plasma membrane]
(Mus musculus)
Tas2r136 [plasma membrane]
(Rattus norvegicus)
t2r14 [plasma membrane]
(Xenopus tropicalis)
t2r9 [plasma membrane]
(Xenopus tropicalis)
t2r3 [plasma membrane]
(Xenopus tropicalis)
t2r19 [plasma membrane]
(Xenopus tropicalis)
TAS2R7 [plasma membrane]
(Gallus gallus)
TAS2R31 [plasma membrane]
(Bos taurus)
t2r42 [plasma membrane]
(Xenopus tropicalis)
t2r35 [plasma membrane]
(Xenopus tropicalis)
t2r8 [plasma membrane]
(Xenopus tropicalis)
t2r48 [plasma membrane]
(Xenopus tropicalis)
LOC100494566 [plasma membrane]
(Xenopus tropicalis)
t2r15 [plasma membrane]
(Xenopus tropicalis)
t2r22 [plasma membrane]
(Xenopus tropicalis)
TAS2R46 [plasma membrane]
(Bos taurus)
Homologues of TAS2R31 [plasma membrane]
(Bos taurus)
Homologues of TAS2R31 [plasma membrane]
(Canis familiaris)
Homologues of TAS2R31 [plasma membrane]
(Mus musculus)
Homologues of TAS2R31 [plasma membrane]
(Rattus norvegicus)
t2r2 [plasma membrane]
(Xenopus tropicalis)
TAS2R20 [plasma membrane]
(Canis familiaris)
TAS2R20 [plasma membrane]
(Xenopus tropicalis)
tas2r39 [plasma membrane]
(Xenopus tropicalis)
LOC108648843 [plasma membrane]
(Xenopus tropicalis)
t2r53 [plasma membrane]
(Xenopus tropicalis)
t2r43 [plasma membrane]
(Xenopus tropicalis)
t2r13 [plasma membrane]
(Xenopus tropicalis)
tas2r7 [plasma membrane]
(Xenopus tropicalis)
TAS2R40 [plasma membrane]
(Gallus gallus)
t2r54 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_795368.2
Guide to Pharmacology - Targets
679
OpenTargets
ENSG00000226761
GeneCards
P59540
HPA
ENSG00000226761-TAS2R46
Ensembl
ENSP00000436450
,
ENST00000574263
,
ENST00000533467
,
ENSG00000262525
,
ENSP00000460229
,
ENSG00000226761
PRO
P59540
Pharos - Targets
P59540
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