Reactome | TAS2R46 [plasma membrane]

TAS2R46 [plasma membrane]

Stable Identifier

R-HSA-3299610

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 46, T2R46_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R46 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R46 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R46 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R46 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        GPCRs that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R46 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R46 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R46 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R46 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P59540 TAS2R46

Gene Names

TAS2R46

Chain

chain:1-309

Reference Genes

BioGPS Gene:259292 TAS2R46

COSMIC (genes):TAS2R46 TAS2R46

CTD Gene:259292 TAS2R46

dbSNP Gene:259292 TAS2R46

ENSEMBL:ENSG00000226761 TAS2R46

ENSEMBL:ENSG00000262525 TAS2R46

HGNC:18877 TAS2R46

KEGG Gene (Homo sapiens):259292 TAS2R46

Monarch:259292 TAS2R46

NCBI Gene:259292 TAS2R46

OMIM:612774 TAS2R46

UCSC:P59540 TAS2R46

Reference Transcript

RefSeq:NM_176887.2 TAS2R46

Other Identifiers

0002370592

11742393_at

11742394_x_at

16761521

259292

3444526

3444527

3444556

7961293

A0A0J9YY42

A_23_P376114

AAM19318

AAM63541

AAU21143

AF494227

AY114091

AY724941

CCDS53748

ENSG00000226761

ENSG00000262525

ENSP00000436450

ENSP00000460229

ENST00000533467

ENST00000533467.1

ENST00000574263

EntrezGene:259292

EntrezGene:TAS2R46

GE903053

GO:0001580

GO:0003674

GO:0004930

GO:0005575

GO:0005623

GO:0005886

GO:0005929

GO:0007165

GO:0007186

GO:0008150

GO:0016020

GO:0016021

GO:0033038

GO:0042995

GO:0043226

GO:0050877

GO:0050896

GO:0050909

GO:0060170

HGNC:18877

ILMN_1811572

IPR007960

MIM:612774

NM_176887

NP_795368

PF05296

TAS2R46

TAS2R46-201

TAS2R46-202

TC12001240.hg

UPI000000D821

Participant Of

hasMember

TAS2Rs [plasma membrane]

Inferred To

TAS2R20 [plasma membrane] (Bos taurus)

TAS2R20 [plasma membrane] (Canis familiaris)

TAS2R20 [plasma membrane] (Danio rerio)

TAS2R20 [plasma membrane] (Gallus gallus)

TAS2R20 [plasma membrane] (Mus musculus)

TAS2R20 [plasma membrane] (Rattus norvegicus)

TAS2R20 [plasma membrane] (Sus scrofa)

TAS2R20 [plasma membrane] (Xenopus tropicalis)

Homologues of TAS2R20 [plasma membrane] (Bos taurus)

Homologues of TAS2R20 [plasma membrane] (Danio rerio)

Homologues of TAS2R20 [plasma membrane] (Gallus gallus)

Homologues of TAS2R20 [plasma membrane] (Mus musculus)

Homologues of TAS2R20 [plasma membrane] (Rattus norvegicus)

Homologues of TAS2R20 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_795368.2

OpenTargets

ENSG00000226761

GeneCards

P59540

PRO

P59540