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TAS2R40 [plasma membrane]
Stable Identifier
R-HSA-3299608
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Taste receptor type 2 member 40, T2R40_HUMAN
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)
TAS2R:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan) [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R40:ligand [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R40:ligand [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R40:ligand [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R40:ligand [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R40:ligand [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T2Rs bind bitter-tasting compounds (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R40 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P59535 TAS2R40
Gene Names
TAS2R40, GPR60
Chain
chain:1-323
Reference Genes
BioGPS Gene:259286 TAS2R40
COSMIC (genes):TAS2R40 TAS2R40
CTD Gene:259286 TAS2R40
dbSNP Gene:259286 TAS2R40
ENSEMBL:ENSG00000221937 TAS2R40
HGNC:18885 TAS2R40
KEGG:hsa:259286 TAS2R40
Monarch:259286 TAS2R40
NCBI Gene:259286 TAS2R40
OMIM:613964 TAS2R40
UCSC:P59535 TAS2R40
Reference Transcript
RefSeq:NM_176882.1 TAS2R40
Other Identifiers
11738555_at
1553556_PM_at
1553556_at
17052746
259286
3028967
3028968
3028969
8136846
ADDON002840.hg
A_14_P101487
A_23_P339652
GE567161
GO:0001580
GO:0004930
GO:0005886
GO:0007186
GO:0016020
GO:0033038
GO:0050877
GO:0050909
GO:0060089
HMNXSV003032708
Hs2Affx.1.33.S1_3p_at
ILMN_1760732
TC07000929.hg
Participates
as a member of
TAS2R (non-orphan) [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
as a component of
TAS2R40:ligand [plasma membrane] (Homo sapiens)
Inferred To
t2r14 [plasma membrane]
(Xenopus tropicalis)
t2r2 [plasma membrane]
(Xenopus tropicalis)
t2r3 [plasma membrane]
(Xenopus tropicalis)
Homologues of TAS2R40 [plasma membrane]
(Danio rerio)
Homologues of TAS2R40 [plasma membrane]
(Gallus gallus)
Homologues of TAS2R40 [plasma membrane]
(Xenopus tropicalis)
TAS2R7 [plasma membrane]
(Gallus gallus)
tas2r200.1 [plasma membrane]
(Danio rerio)
tas2r7 [plasma membrane]
(Xenopus tropicalis)
TAS2R40 [plasma membrane]
(Bos taurus)
TAS2R40 [plasma membrane]
(Canis familiaris)
TAS2R40 [plasma membrane]
(Gallus gallus)
TAS2R40 [plasma membrane]
(Sus scrofa)
t2r15 [plasma membrane]
(Xenopus tropicalis)
tas2r4 [plasma membrane]
(Xenopus tropicalis)
tas2r200.2 [plasma membrane]
(Danio rerio)
Tas2r40 [plasma membrane]
(Mus musculus)
Tas2r40 [plasma membrane]
(Rattus norvegicus)
LOC101747503 [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
NP_795363.1
Guide to Pharmacology - Targets
676
ENSEMBL
ENST00000408947
,
ENSP00000386210
OpenTargets
ENSG00000221937
HPA
ENSG00000221937-TAS2R40
PRO
P59535
Pharos - Targets
P59535
GlyGen
P59535
HMDB Protein
HMDBP08040
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