Reactome | TAS2R42 [plasma membrane]

TAS2R42 [plasma membrane]

Stable Identifier

R-HSA-3299605

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 42, T2R42_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R42 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R42 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R42 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R42 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R42 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R42 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R42 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R42 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7RTR8 TAS2R42

Gene Names

TAS2R42, TAS2R55

Chain

chain:1-314

Reference Genes

BioGPS Gene:353164 TAS2R42

COSMIC (genes):TAS2R42 TAS2R42

CTD Gene:353164 TAS2R42

dbSNP Gene:353164 TAS2R42

ENSEMBL:ENSG00000186136 TAS2R42

ENSEMBL_homo_sapiens_GENE:ENSG00000186136.1 TAS2R42

ENSEMBL_homo_sapiens_GENE:ENSG00000273505.1 TAS2R42

HGNC:18888 TAS2R42

KEGG Gene (Homo sapiens):353164 TAS2R42

Monarch:353164 TAS2R42

NCBI Gene:353164 TAS2R42

OMIM:613966 TAS2R42

UCSC:Q7RTR8 TAS2R42

Reference Transcript

RefSeq:NM_181429.2 TAS2R42

Other Identifiers

11738923_at

16761533

3444579

3444589

3444590

3444591

3444592

353164

4053708

4053710

4053728

7961298

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0016020

GO:0023052

GO:0050877

GO:0050896

GO:0050909

GO:0060089

HMNXSV003000558

ILMN_1707668

TC12001245.hg

Participates

as a member of

TAS2Rs [plasma membrane] (Homo sapiens)

Inferred To

t2r14 [plasma membrane] (Xenopus tropicalis)

t2r2 [plasma membrane] (Xenopus tropicalis)

tas2r1a [plasma membrane] (Danio rerio)

T2R65A [plasma membrane] (Bos taurus)

TAS2R1b [plasma membrane] (Danio rerio)

t2r3 [plasma membrane] (Xenopus tropicalis)

Tas2r131 [plasma membrane] (Mus musculus)

TAS2R42 [plasma membrane] (Bos taurus)

TAS2R42 [plasma membrane] (Canis familiaris)

TAS2R7 [plasma membrane] (Gallus gallus)

Homologues of TAS2R42 [plasma membrane] (Bos taurus)

Homologues of TAS2R42 [plasma membrane] (Danio rerio)

Homologues of TAS2R42 [plasma membrane] (Gallus gallus)

Homologues of TAS2R42 [plasma membrane] (Xenopus tropicalis)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

Tas2r145 [plasma membrane] (Rattus norvegicus)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_852094.2

Guide to Pharmacology - Targets

672

OpenTargets

ENSG00000186136

GeneCards

Q7RTR8

HPA

ENSG00000186136-TAS2R42

Ensembl

ENST00000334266, ENSG00000186136, ENSP00000334050

PRO

Q7RTR8

Pharos - Targets

Q7RTR8