Reactome | TAS2R9 [plasma membrane]

TAS2R9 [plasma membrane]

Stable Identifier

R-HSA-3299604

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 9, TA2R9_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R9 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R9 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R9 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R9 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R9 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R9 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R9 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R9 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYW1 TAS2R9

Gene Names

TAS2R9

Chain

chain:1-312

Reference Genes

BioGPS Gene:50835 TAS2R9

COSMIC (genes):TAS2R9 TAS2R9

CTD Gene:50835 TAS2R9

dbSNP Gene:50835 TAS2R9

ENSEMBL:ENSG00000121381 TAS2R9

ENSEMBL_homo_sapiens_GENE:ENSG00000121381.4 TAS2R9

ENSEMBL_homo_sapiens_GENE:ENSG00000273086.1 TAS2R9

ENSEMBL_homo_sapiens_GENE:ENSG00000273713.2 TAS2R9

HGNC:14917 TAS2R9

KEGG Gene (Homo sapiens):50835 TAS2R9

Monarch:50835 TAS2R9

NCBI Gene:50835 TAS2R9

OMIM:604795 TAS2R9

UCSC:Q9NYW1 TAS2R9

Reference Transcript

RefSeq:NM_023917.2 TAS2R9

Other Identifiers

11738575_at

16761460

221461_PM_at

221461_at

3444310

3444311

3444312

50835

7961245

A_23_P336506

GE538016

GO:0001580

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0008150

GO:0008527

GO:0016020

GO:0023052

GO:0033038

GO:0050877

GO:0050896

GO:0050909

GO:0060089

HMNXSV003026323

ILMN_1732309

PH_hs_0014067

TC12001230.hg

g12965171_3p_at

Participates

as a member of

TAS2Rs [plasma membrane] (Homo sapiens)

Inferred To

t2r14 [plasma membrane] (Xenopus tropicalis)

t2r2 [plasma membrane] (Xenopus tropicalis)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

TAS2R9 [plasma membrane] (Sus scrofa)

tas2r200.1 [plasma membrane] (Danio rerio)

tas2r7 [plasma membrane] (Xenopus tropicalis)

Homologues of TAS2R9 [plasma membrane] (Danio rerio)

Homologues of TAS2R9 [plasma membrane] (Gallus gallus)

Homologues of TAS2R9 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

tas2r200.2 [plasma membrane] (Danio rerio)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_076406.1

Guide to Pharmacology - Targets

665

OpenTargets

ENSG00000121381

GeneCards

Q9NYW1

HPA

ENSG00000121381-TAS2R9

ZINC target

Q9NYW1

Ensembl

ENSG00000121381, ENST00000240691, ENST00000573524, ENSP00000460247, ENST00000616297, ENSP00000240691, ENSG00000273713, ENSG00000273086, ENSP00000480069

PRO

Q9NYW1

Pharos - Targets

Q9NYW1

HMDB Protein

HMDBP08044