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TLE2 tetramer [nucleoplasm]
Stable Identifier
R-HSA-3299554
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Repression of WNT target genes (Homo sapiens)
TLE oligomerizes (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE recruits HDAC1 to WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
XIAP binds TLE (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE:XIAP [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
XIAP monoubiquinates TLE (Homo sapiens)
TLE:XIAP [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15768032
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
Weis, WI
,
Daniels, DL
Nat Struct Mol Biol
2005
Participants
components
x 4
TLE2 [nucleoplasm]
(Homo sapiens)
Participates
as a member of
TLE tetramer [nucleoplasm] (Homo sapiens)
Inferred To
TLE2 tetramer [nucleoplasm]
(Bos taurus)
TLE2 tetramer [nucleoplasm]
(Caenorhabditis elegans)
TLE2 tetramer [nucleoplasm]
(Canis familiaris)
TLE2 tetramer [nucleoplasm]
(Danio rerio)
TLE2 tetramer [nucleoplasm]
(Drosophila melanogaster)
TLE2 tetramer [nucleoplasm]
(Gallus gallus)
TLE2 tetramer [nucleoplasm]
(Mus musculus)
TLE2 tetramer [nucleoplasm]
(Rattus norvegicus)
TLE2 tetramer [nucleoplasm]
(Sus scrofa)
TLE2 tetramer [nucleoplasm]
(Xenopus tropicalis)
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