HCAR1 binds LACT

Stable Identifier
R-HSA-3296326
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
HCAR1 binds L-lactate
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HCAR1 binds LACT
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HCAR1 (GPR81) binds L-lactate (2-hydroxy-propanoic acid) (Cai et al. 2008).

Literature References
PubMed ID Title Journal Year
19047060 Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81

Liu, C, Wu, J, Zhu, J, Kuei, C, Yu, J, Shelton, J, Sutton, SW, Li, X, Yun, SJ, Mirzadegan, T, Mazur, C, Kamme, F, Lovenberg, TW

J. Biol. Chem. 2009
18952058 Role of GPR81 in lactate-mediated reduction of adipose lipolysis

Cai, TQ, Ren, N, Jin, L, Cheng, K, Kash, S, Chen, R, Wright, SD, Taggart, AK, Waters, MG

Biochem. Biophys. Res. Commun. 2008
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
HCAR1 binds LACT (Bos taurus)
HCAR1 binds LACT (Canis familiaris)
HCAR1 binds LACT (Danio rerio)
HCAR1 binds LACT (Mus musculus)
HCAR1 binds LACT (Rattus norvegicus)
HCAR1 binds LACT (Sus scrofa)
HCAR1 binds LACT (Xenopus tropicalis)
Authored
Jupe, S  (2013-04-18)
Reviewed
D'Eustachio, P  (2013-05-17)
Created
Jupe, S  (2013-04-18)