GPR31 binds with high affinity the 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(S)-HETE). 12-(S)-HETE/GPR31-mediated ERK1/2 activation was inhibited by pertussis toxin, suggesting that the involvement of the G-alpha-i/o heterotrimeric G proteins.
Zhang, W, Maddipati, KR, Zhou, S, Lee, MJ, Liu, J, Cai, Y, Honn, KV, Giroux, C, Tucker, SC, Hsu, A, Ekambaram, P, Joshi, S, Dilly, AK, Guo, Y
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