GPR31 is a receptor for 12(S)-HETE

Stable Identifier
R-HSA-3296304
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GPR31 binds with high affinity the 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(S)-HETE). 12-(S)-HETE/GPR31-mediated ERK1/2 activation was inhibited by pertussis toxin, suggesting that the involvement of the G-alpha-i/o heterotrimeric G proteins.

Literature References
PubMed ID Title Journal Year
21712392 Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid

Guo, Y, Zhang, W, Giroux, C, Cai, Y, Ekambaram, P, Dilly, AK, Hsu, A, Zhou, S, Maddipati, KR, Liu, J, Joshi, S, Tucker, SC, Lee, MJ, Honn, KV

J. Biol. Chem. 2011
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