GPR31 is a receptor for 12(S)-HETE

Stable Identifier
R-HSA-3296304
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
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GPR31 is a receptor for 12(S)-HETE
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GPR31 binds with high affinity the 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(S)-HETE). 12-(S)-HETE/GPR31-mediated ERK1/2 activation was inhibited by pertussis toxin, suggesting that the involvement of the G-alpha-i/o heterotrimeric G proteins.

Literature References
PubMed ID Title Journal Year
21712392 Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid

Zhang, W, Maddipati, KR, Zhou, S, Lee, MJ, Liu, J, Cai, Y, Honn, KV, Giroux, C, Tucker, SC, Hsu, A, Ekambaram, P, Joshi, S, Dilly, AK, Guo, Y

J. Biol. Chem. 2011
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Orthologous Events
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GPR31 is a receptor for 12(S)-HETE (Rattus norvegicus)
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Authored
Jupe, S  (2013-01-09)
Reviewed
D'Eustachio, P  (2013-05-17)
Created
Jupe, S  (2013-04-18)
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