GPR31 binds with high affinity the 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(S)-HETE). 12-(S)-HETE/GPR31-mediated ERK1/2 activation was inhibited by pertussis toxin, suggesting that the involvement of the G-alpha-i/o heterotrimeric G proteins.
Guo, Y, Zhang, W, Giroux, C, Cai, Y, Ekambaram, P, Dilly, AK, Hsu, A, Zhou, S, Maddipati, KR, Liu, J, Joshi, S, Tucker, SC, Lee, MJ, Honn, KV
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