GPR31 is a receptor for 12(S)-HETE

Stable Identifier
R-HSA-3296304
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GPR31 is a receptor for 12(S)-HETE
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GPR31 binds with high affinity the 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(S)-HETE). 12-(S)-HETE/GPR31-mediated ERK1/2 activation was inhibited by pertussis toxin, suggesting that the involvement of the G-alpha-i/o heterotrimeric G proteins.

Literature References
PubMed ID Title Journal Year
21712392 Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid

Guo, Y, Zhang, W, Giroux, C, Cai, Y, Ekambaram, P, Dilly, AK, Hsu, A, Zhou, S, Maddipati, KR, Liu, J, Joshi, S, Tucker, SC, Lee, MJ, Honn, KV

J. Biol. Chem. 2011
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
GPR31 is a receptor for 12(S)-HETE (Bos taurus)
GPR31 is a receptor for 12(S)-HETE (Canis familiaris)
GPR31 is a receptor for 12(S)-HETE (Danio rerio)
GPR31 is a receptor for 12(S)-HETE (Mus musculus)
GPR31 is a receptor for 12(S)-HETE (Rattus norvegicus)
GPR31 is a receptor for 12(S)-HETE (Sus scrofa)
GPR31 is a receptor for 12(S)-HETE (Xenopus tropicalis)
Authored
Jupe, S  (2013-01-09)
Reviewed
D'Eustachio, P  (2013-05-17)
Created
Jupe, S  (2013-04-18)