SUCNR1 binds SUCCA

Stable Identifier
R-HSA-3296244
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
SUCNR1 binds succinate
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SUCNR1 binds SUCCA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SUCNR1 (GPR91) is activated by the citric acid cycle intermediate succinate (SUCCA) (He et al. 2004), signalling via Gi to have a role in the stimulation of hematopoietic progenitor cell (HPC) growth (Hakak et al. 2009).
Literature References
PubMed ID Title Journal Year
15141213 Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

He, W, Miao, FJ, Lin, DC, Schwandner, RT, Wang, Z, Gao, J, Chen, JL, Tian, H, Ling, L

Nature 2004
Participants
Input
Output
Participates
as an event of
Orthologous Events
SUCNR1 binds SUCCA (Bos taurus)
SUCNR1 binds SUCCA (Canis familiaris)
SUCNR1 binds SUCCA (Gallus gallus)
SUCNR1 binds SUCCA (Mus musculus)
SUCNR1 binds SUCCA (Rattus norvegicus)
SUCNR1 binds SUCCA (Sus scrofa)
Authored
Jupe, S  (2013-04-18)
Reviewed
D'Eustachio, P  (2013-05-17)
Created
Jupe, S  (2013-04-18)
Cite Us!