SUCNR1 binds SUCCA

Stable Identifier
R-HSA-3296244
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
SUCNR1 binds succinate
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SUCNR1 binds SUCCA
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SUCNR1 (GPR91) is activated by the citric acid cycle intermediate succinate (SUCCA) (He et al. 2004), signalling via Gi to have a role in the stimulation of hematopoietic progenitor cell (HPC) growth (Hakak et al. 2009).

Literature References
PubMed ID Title Journal Year
15141213 Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

Lin, DC, Miao, FJ, Ling, L, Wang, Z, Gao, J, Schwandner, RT, Chen, JL, He, W, Tian, H

Nature 2004
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Orthologous Events
SUCNR1 binds SUCCA (Bos taurus)
SUCNR1 binds SUCCA (Canis familiaris)
SUCNR1 binds SUCCA (Gallus gallus)
SUCNR1 binds SUCCA (Mus musculus)
SUCNR1 binds SUCCA (Rattus norvegicus)
SUCNR1 binds SUCCA (Sus scrofa)
SUCNR1 binds SUCCA (Xenopus tropicalis)
Authored
Jupe, S  (2013-04-18)
Reviewed
D'Eustachio, P  (2013-05-17)
Created
Jupe, S  (2013-04-18)
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