p-S407-STAT6 is phosphorylated at Tyr641

Stable Identifier
R-HSA-3249379
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TBK1 phosphorylates STAT6 on Ser407, which in turn activates another unidentified tyrosine kinase to phosphorylate STAT6 on Tyr641. Mutant constructs with Tyr641 replaced by Phe totally abolished STAT6 activity in response to virus or IL-4/IL-13 (Chen H et al. 2011).

Literature References
PubMed ID Title Journal Year
22000020 Activation of STAT6 by STING is critical for antiviral innate immunity

Chen, H, Sun, H, You, F, Sun, W, Zhou, X, Chen, L, Yang, J, Wang, Y, Tang, H, Guan, Y, Xia, W, Gu, J, Ishikawa, H, Gutman, D, Barber, G, Qin, Z, Jiang, Z

Cell 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created