Reactome | p-S407-STAT6 is phosphorylated at Tyr641

p-S407-STAT6 is phosphorylated at Tyr641

Stable Identifier

R-HSA-3249379

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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p-S407-STAT6 is phosphorylated at Tyr641

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TBK1 phosphorylates STAT6 on Ser407, which in turn activates another unidentified tyrosine kinase to phosphorylate STAT6 on Tyr641. Mutant constructs with Tyr641 replaced by Phe totally abolished STAT6 activity in response to virus or IL-4/IL-13 (Chen H et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
22000020	Activation of STAT6 by STING is critical for antiviral innate immunity Yang, J, Qin, Z, Chen, H, Guan, Y, Zhou, X, Barber, G, Jiang, Z, Sun, H, Ishikawa, H, You, F, Sun, W, Gutman, D, Tang, H, Chen, L, Wang, Y, Gu, J, Xia, W	Cell	2011