Upon viral infection STAT6 undergoes Ser407 phosphorylation, which was shown to depend on the TBK1 kinase activity, but not on the kinase JAK, which phosphorylates STAT6 on Tyr641 in IL4-mediated signaling (Chen H et al. 2011).
Yang, J, Qin, Z, Chen, H, Guan, Y, Zhou, X, Barber, G, Jiang, Z, Sun, H, Ishikawa, H, You, F, Sun, W, Gutman, D, Tang, H, Chen, L, Wang, Y, Gu, J, Xia, W
protein serine/threonine kinase activity of STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane]
© 2023 Reactome
