TBK1 phosphorylates STAT6 at Ser407

Stable Identifier
R-HSA-3249371
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Upon viral infection STAT6 undergoes Ser407 phosphorylation, which was shown to depend on the TBK1 kinase activity, but not on the kinase JAK, which phosphorylates STAT6 on Tyr641 in IL4-mediated signaling (Chen H et al. 2011).

Literature References
PubMed ID Title Journal Year
22000020 Activation of STAT6 by STING is critical for antiviral innate immunity

Chen, H, Sun, H, You, F, Sun, W, Zhou, X, Chen, L, Yang, J, Wang, Y, Tang, H, Guan, Y, Xia, W, Gu, J, Ishikawa, H, Gutman, D, Barber, G, Qin, Z, Jiang, Z

Cell 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created