Reactome | TBK1 phosphorylates STAT6 at Ser407

TBK1 phosphorylates STAT6 at Ser407

Stable Identifier

R-HSA-3249371

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, cytoplasmic vesicle membrane

ReviewStatus

5/5

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Upon viral infection STAT6 undergoes Ser407 phosphorylation, which was shown to depend on the TBK1 kinase activity, but not on the kinase JAK, which phosphorylates STAT6 on Tyr641 in IL4-mediated signaling (Chen H et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
22000020	Activation of STAT6 by STING is critical for antiviral innate immunity Yang, J, Qin, Z, Chen, H, Guan, Y, Zhou, X, Barber, G, Jiang, Z, Sun, H, Ishikawa, H, You, F, Sun, W, Gutman, D, Tang, H, Chen, L, Wang, Y, Gu, J, Xia, W	Cell	2011