p-S407,Y641-STAT6 dimer migrates to the nucleus

Stable Identifier
R-HSA-3249370
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Following tyrosine phosphorylation and dimerization STAT6 translocates to the nucleus to initiate the transcription. Virus-induced STAT6 was shown to up-regulate expression of the specific gene set (Chen H et al. 2011). Among the targets are chemokines CCL2, CCL20, and CCL26, which attract cells of immune system to fight the infection.

Literature References
PubMed ID Title Journal Year
22000020 Activation of STAT6 by STING is critical for antiviral innate immunity

Chen, H, Sun, H, You, F, Sun, W, Zhou, X, Chen, L, Yang, J, Wang, Y, Tang, H, Guan, Y, Xia, W, Gu, J, Ishikawa, H, Gutman, D, Barber, G, Qin, Z, Jiang, Z

Cell 2011
Participants
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Orthologous Events
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Created