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Retromer recycles WLS to the Golgi
Stable Identifier
R-HSA-3247836
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Golgi membrane
,
early endosome membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
WNT ligand biogenesis and trafficking (Homo sapiens)
Retromer recycles WLS to the Golgi (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Retromer is believed to escort WLS from the early endosome back to the Golgi for subsequent rounds of WNT secretion (reviewed in Johannes and Wunder, 2011; Willert and Nusse, 2012 ).
Literature References
PubMed ID
Title
Journal
Year
22952392
Wnt proteins
Nusse, R
,
Willert, K
Cold Spring Harb Perspect Biol
2012
21725318
The SNXy flavours of endosomal sorting
Wunder, C
,
Johannes, L
Nat. Cell Biol.
2011
Participants
Input
WLS:retromer [early endosome membrane]
(Homo sapiens)
Output
WLS:retromer [Golgi membrane]
(Homo sapiens)
Participates
as an event of
WNT ligand biogenesis and trafficking (Homo sapiens)
Orthologous Events
Retromer recycles WLS to the Golgi (Bos taurus)
Retromer recycles WLS to the Golgi (Caenorhabditis elegans)
Retromer recycles WLS to the Golgi (Canis familiaris)
Retromer recycles WLS to the Golgi (Dictyostelium discoideum)
Retromer recycles WLS to the Golgi (Drosophila melanogaster)
Retromer recycles WLS to the Golgi (Gallus gallus)
Retromer recycles WLS to the Golgi (Mus musculus)
Retromer recycles WLS to the Golgi (Rattus norvegicus)
Retromer recycles WLS to the Golgi (Saccharomyces cerevisiae)
Retromer recycles WLS to the Golgi (Schizosaccharomyces pombe)
Retromer recycles WLS to the Golgi (Sus scrofa)
Retromer recycles WLS to the Golgi (Xenopus tropicalis)
Authored
Rothfels, K (2013-04-06)
Reviewed
Boutros, M (2013-05-24)
Created
Rothfels, K (2013-04-06)
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