Reactome | N4GlycoAsn-PalmS WNT3A [extracellular region]

N4GlycoAsn-PalmS WNT3A [extracellular region]

Stable Identifier

R-HSA-3247784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

N4GlycoAsn-O-palmitoleyl-L-serine-WNT3A, palmitoleyl-N-glycosyl WNT3A, palmitoleoyl-N-glycosyl WNT3A

Locations in the PathwayBrowser for interactor UniProt:Q9H461 FZD8

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External Reference Information

External Reference

UniProt:P56704 WNT3A

Gene Names

WNT3A

Chain

signal peptide:1-18, chain:19-352

Reference Genes

BioGPS Gene:89780 WNT3A

COSMIC (genes):WNT3A WNT3A

CTD Gene:89780 WNT3A

dbSNP Gene:89780 WNT3A

ENSEMBL:ENSG00000154342 WNT3A

ENSEMBL_homo_sapiens_GENE:ENSG00000154342.6 WNT3A

HGNC:15983 WNT3A

KEGG Gene (Homo sapiens):89780 WNT3A

Monarch:89780 WNT3A

NCBI Gene:89780 WNT3A

OMIM:606359 WNT3A

UCSC:P56704 WNT3A

Reference Transcript

RefSeq:NM_033131.3 WNT3A

Other Identifiers

11734990_at

11734991_a_at

11745684_a_at

16678295

2383708

2383709

2383715

2383721

2383724

2383725

7910217

89780

A_14_P122078

A_23_P385690

A_33_P3417502

GE507271

GO:0001649

GO:0001701

GO:0001756

GO:0001819

GO:0001934

GO:0001947

GO:0002092

GO:0002376

GO:0003713

GO:0005102

GO:0005109

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0005768

GO:0005783

GO:0005788

GO:0005794

GO:0005796

GO:0005886

GO:0006351

GO:0006355

GO:0006366

GO:0007010

GO:0007155

GO:0007275

GO:0007368

GO:0007409

GO:0007411

GO:0007498

GO:0007507

GO:0008104

GO:0008283

GO:0008284

GO:0009952

GO:0009986

GO:0010387

GO:0010468

GO:0010628

GO:0010977

GO:0016055

GO:0016192

GO:0019904

GO:0021527

GO:0021766

GO:0021846

GO:0021874

GO:0021904

GO:0022008

GO:0023052

GO:0030097

GO:0030154

GO:0030168

GO:0030182

GO:0030198

GO:0030666

GO:0030879

GO:0030890

GO:0030901

GO:0031410

GO:0031901

GO:0033138

GO:0033278

GO:0034330

GO:0035567

GO:0035914

GO:0036211

GO:0036342

GO:0036465

GO:0039706

GO:0042060

GO:0042100

GO:0042472

GO:0042802

GO:0043226

GO:0045165

GO:0045202

GO:0045444

GO:0045445

GO:0045595

GO:0045599

GO:0045893

GO:0045944

GO:0048018

GO:0048103

GO:0048337

GO:0048343

GO:0048643

GO:0048697

GO:0048843

GO:0048856

GO:0050768

GO:0050770

GO:0050804

GO:0050807

GO:0055085

GO:0060070

GO:0060923

GO:0061184

GO:0062009

GO:0065003

GO:0070062

GO:0070507

GO:0070527

GO:0071300

GO:0072659

GO:0090245

GO:0090263

GO:0090676

GO:0098772

GO:0098793

GO:0098978

GO:0099054

GO:0140110

GO:1903078

GO:1904339

GO:1904948

GO:1905539

GO:1905606

GO:1990851

GO:2000049

GO:2000081

GO:2000179

GO:2000347

GO:2000727

GO:2001141

HMNXSV003010642

ILMN_1815700

PH_hs_0016549

TC01001883.hg

Participates

as an input of

sFRP binds WNT3A and inhibits WNT:FZD binding (Homo sapiens)

as a component of

as a member of

This entity regulates

Negatively

GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 (Homo sapiens)

Positively

Other forms of this molecule

N4GlycoAsn-PalmS WNT3A [plasma membrane]

N4GlycoAsn-PalmS WNT3A [Golgi lumen]

N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen]

N4GlycoAsn-WNT3A [endoplasmic reticulum lumen]

WNT3A [endoplasmic reticulum lumen]

N4GlycoAsn-PalmS WNT3A [early endosome membrane]

N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane]

N4GlycoAsn-PalmS WNT3A [extracellular exosome]

WNT3A [extracellular region]

Inferred To

Wnt3a [extracellular region] (Mus musculus)

Wnt3a [extracellular region] (Rattus norvegicus)

WNT3A [extracellular region] (Bos taurus)

WNT3A [extracellular region] (Canis familiaris)

WNT3A [extracellular region] (Gallus gallus)

WNT3A [extracellular region] (Sus scrofa)

wnt3a [extracellular region] (Danio rerio)

wnt3a [extracellular region] (Xenopus tropicalis)

Ghost homologue of N4GlycoAsn-PalmS WNT3A [extracellular region] (Caenorhabditis elegans)

Modified Residues

Name

N4-glycosyl-L-asparagine at unknown position

PsiMod Name

N4-glycosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.

Name

O-palmitoleyl-L-serine at 209

Coordinate

209

PsiMod Name

O-palmitoleyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine.

Cross References

RefSeq

NP_149122.1

OpenTargets

ENSG00000154342

GeneCards

P56704

ZINC - Substances

WNT3A_HUMAN

HPA

ENSG00000154342-WNT3A

ZINC target

P56704

Ensembl

ENST00000284523, ENSG00000154342, ENSP00000284523

PRO

P56704

Pharos - Targets

P56704

ZINC - Predictions - Purchasable

WNT3A_HUMAN

Orphanet

21408

PDB

7URD, 7DRT, 7URE, 8TZR

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5T9L3 WLS	5	WLS [extracellular exosome] (R-HSA-3781960) WLS [endocytic vesicle membrane] (R-HSA-3781954) WLS [early endosome membrane] (R-HSA-3247745) WLS [Golgi membrane] (R-HSA-3247747) WLS [plasma membrane] (R-HSA-3247746)	0.721	5
UniProt:O75581 LRP6	8	p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) LRP6 [early endosome membrane] (R-HSA-5368481) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6N [extracellular region] (R-HSA-5334021) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) LRP6 [plasma membrane] (R-HSA-206252)	0.702	3
UniProt:Q15172 PPP2R5A	2	p-S28-PPP2R5A [cytosol] (R-HSA-9836658) PPP2R5A [cytosol] (R-HSA-196235)	0.527	3
UniProt:P56703 WNT3	9	N4GlycoAsn-PalmS WNT3 [plasma membrane] (R-HSA-3247830) N4GlycoAsn-PalmS WNT3 [extracellular region] (R-HSA-3247786) N4GlycoAsn-PalmS WNT3 [Golgi lumen] (R-HSA-3247818) N4GlycoAsn-PalmS WNT3 [endoplasmic reticulum lumen] (R-HSA-3238342) N4GlycoAsn-WNT3 [endoplasmic reticulum lumen] (R-HSA-3238227) WNT3 [endoplasmic reticulum lumen] (R-HSA-3238288) N4GlycoAsn-PalmS WNT3 [endocytic vesicle membrane] (R-HSA-3781967) N4GlycoAsn-PalmS WNT3 [extracellular exosome] (R-HSA-3781966) WNT3 [extracellular region] (R-HSA-201676)	0.527	2
UniProt:Q9UK73 FEM1B	1	FEM1B [cytosol] (R-HSA-201572)	0.527	2
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	3
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.527	2
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.527	3
UniProt:Q8J025 APCD1			0.524	3
UniProt:Q9H461 FZD8	2	ub-FZD8 [plasma membrane] (R-HSA-4641183) FZD8 [plasma membrane] (R-HSA-443947)	0.499	2

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