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N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region]
Stable Identifier
R-HSA-3247777
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
N4GlycoAsn-O-palmitoleyl-L-serine-WNT5A(36-380), palmitoleyl-N-glycosyl WNT5A, palmitoyleoyl-N-glycosyl WNT5A
Locations in the PathwayBrowser for interactor UniProt:Q5T9L3 WLS
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Killing mechanisms (Homo sapiens)
WNT5:FZD7-mediated leishmania damping (Homo sapiens)
WNT5 binds FZD7 (Homo sapiens)
N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)
N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] (Homo sapiens)
RYK binds WNT5A and VANGL2 (Homo sapiens)
N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] (Homo sapiens)
WNT5A binds ROR2 and VANGL2 (Homo sapiens)
N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] (Homo sapiens)
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Homo sapiens)
WNT5A binds FZD and ROR receptors (Homo sapiens)
N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] (Homo sapiens)
WNT5A-dependent internalization of FZD4 (Homo sapiens)
WNT5A binds FZD4 (Homo sapiens)
N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41221 WNT5A
Gene Names
WNT5A
Chain
signal peptide:1-35, propeptide:36-61, chain:62-380
Reference Genes
BioGPS Gene:7474 WNT5A
COSMIC (genes):WNT5A WNT5A
CTD Gene:7474 WNT5A
dbSNP Gene:7474 WNT5A
ENSEMBL:ENSG00000114251 WNT5A
ENSEMBL_homo_sapiens_GENE:ENSG00000114251.15 WNT5A
HGNC:12784 WNT5A
KEGG Gene (Homo sapiens):7474 WNT5A
Monarch:7474 WNT5A
NCBI Gene:7474 WNT5A
OMIM:164975 WNT5A
UCSC:P41221 WNT5A
Reference Transcript
RefSeq:XM_011534088.2 WNT5A
RefSeq:NM_001256105.1 WNT5A
RefSeq:XM_011534085.2 WNT5A
RefSeq:XM_011534086.2 WNT5A
RefSeq:XM_011534089.1 WNT5A
RefSeq:NM_003392.4 WNT5A
RefSeq:XM_017007128.1 WNT5A
RefSeq:XM_006713324.1 WNT5A
RefSeq:XM_011534087.2 WNT5A
Other Identifiers
11727186_a_at
11727187_a_at
11727188_at
11727189_x_at
11753677_a_at
1669_at
16955197
205990_PM_s_at
205990_s_at
213425_PM_at
213425_at
2677357
2677358
2677359
2677360
2677361
2677363
2677366
2677367
2677370
2677371
2677372
2677374
2677379
2677380
2677381
31862_at
56803_at
7474
8088180
A_23_P211926
A_33_P3341499
GE57670
GO:0001736
GO:0001756
GO:0001819
GO:0001822
GO:0001837
GO:0001843
GO:0001934
GO:0001938
GO:0001947
GO:0002009
GO:0002053
GO:0002088
GO:0002376
GO:0002720
GO:0003138
GO:0003139
GO:0003281
GO:0003283
GO:0003323
GO:0003344
GO:0003401
GO:0003402
GO:0003408
GO:0005102
GO:0005109
GO:0005115
GO:0005125
GO:0005515
GO:0005543
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005886
GO:0006351
GO:0006355
GO:0006954
GO:0007155
GO:0007163
GO:0007223
GO:0007254
GO:0007275
GO:0007368
GO:0007409
GO:0007411
GO:0007442
GO:0007494
GO:0008104
GO:0008283
GO:0008289
GO:0008543
GO:0008584
GO:0008595
GO:0009952
GO:0009986
GO:0010033
GO:0010463
GO:0010595
GO:0010628
GO:0010631
GO:0010742
GO:0010800
GO:0010820
GO:0010976
GO:0012501
GO:0016055
GO:0016192
GO:0016477
GO:0019904
GO:0021891
GO:0021915
GO:0022008
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030182
GO:0030216
GO:0030312
GO:0030324
GO:0030326
GO:0030509
GO:0030514
GO:0030666
GO:0030669
GO:0030901
GO:0031012
GO:0031410
GO:0032148
GO:0032722
GO:0032729
GO:0032731
GO:0032755
GO:0032757
GO:0032760
GO:0032880
GO:0033138
GO:0034330
GO:0035108
GO:0035567
GO:0036211
GO:0036342
GO:0036517
GO:0036518
GO:0040037
GO:0042060
GO:0042472
GO:0042733
GO:0043032
GO:0043066
GO:0043122
GO:0043226
GO:0043410
GO:0043507
GO:0045165
GO:0045198
GO:0045599
GO:0045732
GO:0045766
GO:0045778
GO:0045807
GO:0045836
GO:0045892
GO:0045893
GO:0045944
GO:0046330
GO:0046546
GO:0048018
GO:0048022
GO:0048146
GO:0048341
GO:0048546
GO:0048570
GO:0048706
GO:0048806
GO:0048812
GO:0048843
GO:0048846
GO:0048850
GO:0048856
GO:0048870
GO:0050673
GO:0050679
GO:0050680
GO:0050727
GO:0050729
GO:0050807
GO:0050919
GO:0051092
GO:0051216
GO:0051885
GO:0051964
GO:0055065
GO:0060026
GO:0060028
GO:0060029
GO:0060065
GO:0060067
GO:0060068
GO:0060070
GO:0060071
GO:0060157
GO:0060324
GO:0060340
GO:0060599
GO:0060606
GO:0060638
GO:0060686
GO:0060744
GO:0060750
GO:0060760
GO:0060762
GO:0060775
GO:0060809
GO:0060907
GO:0061036
GO:0061053
GO:0061347
GO:0061348
GO:0061349
GO:0061350
GO:0061354
GO:0062009
GO:0062023
GO:0070062
GO:0070242
GO:0070245
GO:0071219
GO:0071222
GO:0071277
GO:0071300
GO:0071346
GO:0071425
GO:0071542
GO:0071560
GO:0072089
GO:0072201
GO:0090009
GO:0090037
GO:0090082
GO:0090090
GO:0090103
GO:0090179
GO:0097325
GO:0098542
GO:0098685
GO:0098772
GO:0098794
GO:0098978
GO:0099054
GO:0099068
GO:0099170
GO:0099175
GO:0099566
GO:0140013
GO:0150012
GO:1900020
GO:1902035
GO:1902379
GO:1902474
GO:1904861
GO:1904862
GO:1904934
GO:1904948
GO:2000049
GO:2000052
GO:2000648
GO:2001235
HMNXSV003019230
Hs.152213.2.S1_3p_at
ILMN_1800317
L20861_at
PH_hs_0009158
TC03001482.hg
g4507928_3p_a_at
Participates
as an input of
WNT5 binds FZD7 (Homo sapiens)
WNT5A binds ROR2 and VANGL2 (Homo sapiens)
WNT5A binds FZD4 (Homo sapiens)
WNT5A binds FZD and ROR receptors (Homo sapiens)
RYK binds WNT5A and VANGL2 (Homo sapiens)
WNT5A binding to FZD promotes PRICKLE1 degradation (Homo sapiens)
as a component of
WNT5:FZD7 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS WNT5A:ROR2:p-VANGL2 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS WNT5A:ROR2:VANGL2 [plasma membrane] (Homo sapiens)
WNT5A:FZDs/ROR [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT5A:RYK:VANGL2 [plasma membrane] (Homo sapiens)
WNT5A:FZD [plasma membrane] (Homo sapiens)
as a member of
RYK-binding WNTs [extracellular region] (Homo sapiens)
WIF1-binding WNTs [extracellular region] (Homo sapiens)
WNTs [extracellular region] (Homo sapiens)
as a candidate of
PCP pathway WNTs [extracellular region] (Homo sapiens)
WNT5A/WNT11 [extracellular region] (Homo sapiens)
Other forms of this molecule
WNT5A [extracellular region]
N4GlycoAsn-PalmS WNT5A(36-380) [endocytic vesicle membrane]
N4GlycoAsn-PalmS WNT5A(36-380) [extracellular exosome]
N4GlycoAsn-PalmS WNT5A(36-380) [clathrin-coated endocytic vesicle membrane]
WNT5A(36-380) [endoplasmic reticulum lumen]
N4GlycoAsn-WNT5A(36-380) [endoplasmic reticulum lumen]
N4GlycoAsn-PalmS WNT5A(36-380) [endoplasmic reticulum lumen]
N4GlycoAsn-PalmS WNT5A(36-380) [Golgi lumen]
N4GlycoAsn-PalmS WNT5A(36-380) [plasma membrane]
Inferred To
cwn-2 [extracellular region]
(Caenorhabditis elegans)
WNT5A [extracellular region]
(Bos taurus)
WNT5A [extracellular region]
(Canis familiaris)
WNT5A [extracellular region]
(Gallus gallus)
WNT5A [extracellular region]
(Sus scrofa)
wnt5a [extracellular region]
(Danio rerio)
wnt5a [extracellular region]
(Xenopus tropicalis)
Wnt5a [extracellular region]
(Mus musculus)
Wnt5a [extracellular region]
(Rattus norvegicus)
Wnt5 [extracellular region]
(Drosophila melanogaster)
Modified Residues
Name
N4-glycosyl-L-asparagine at unknown position
PsiMod Name
N4-glycosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.
Name
O-palmitoleyl-L-serine at 244
Coordinate
244
PsiMod Name
O-palmitoleyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine.
Cross References
RefSeq
XP_011532391.1
,
XP_016862617.1
,
XP_011532388.1
,
XP_011532389.1
,
XP_011532387.1
,
XP_006713387.1
,
XP_011532390.1
,
NP_003383.2
,
NP_001243034.1
OpenTargets
ENSG00000114251
GeneCards
P41221
HPA
ENSG00000114251-WNT5A
Ensembl
ENST00000497027
,
ENST00000474267
,
ENSP00000420104
,
ENSP00000417310
,
ENST00000264634
,
ENSG00000114251
,
ENSP00000264634
PRO
P41221
Pharos - Targets
P41221
Orphanet
19181
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5T9L3 WLS
5
WLS [extracellular exosome]
(R-HSA-3781960)
WLS [endocytic vesicle membrane]
(R-HSA-3781954)
WLS [early endosome membrane]
(R-HSA-3247745)
WLS [Golgi membrane]
(R-HSA-3247747)
WLS [plasma membrane]
(R-HSA-3247746)
0.564
3
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