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CGAS [cytosol]
Stable Identifier
R-HSA-3244653
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cGAS, MB21D1, Cyclic GMP-AMP synthase, cGAMP synthase
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
cGAS binds cytosolic DNA (Homo sapiens)
CGAS [cytosol] (Homo sapiens)
cGAS:dsDNA [cytosol] (Homo sapiens)
CGAS [cytosol] (Homo sapiens)
cGAS produces cyclic GMP-AMP (Homo sapiens)
CGAS [cytosol] (Homo sapiens)
cGAS:dsDNA [cytosol] (Homo sapiens)
CGAS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N884 CGAS
Gene Names
CGAS, C6orf150, MB21D1
Chain
chain:1-522
Reference Genes
BioGPS Gene:115004 CGAS
COSMIC (genes):CGAS CGAS
CTD Gene:115004 CGAS
dbSNP Gene:115004 CGAS
ENSEMBL:ENSG00000164430 MB21D1
HGNC:21367 CGAS
KEGG:hsa:115004 CGAS
Monarch:115004 CGAS
NCBI Gene:115004 CGAS
OMIM:613973 CGAS
UCSC:Q8N884 CGAS
Reference Transcript
RefSeq:NM_138441.2 CGAS
Other Identifiers
115004
11741157_a_at
11754870_x_at
1559051_3p_s_at
1559051_PM_s_at
1559051_s_at
1561708_PM_at
1561708_at
17020787
242077_3p_x_at
242077_PM_x_at
242077_x_at
2960873
2960876
2960877
2960878
2960879
2960880
2960881
2960883
2960884
2960886
2960887
2960890
2960892
2960893
53430_r_at
8127534
A_32_P1173
GE505020
GO:0002218
GO:0002221
GO:0002230
GO:0002376
GO:0002637
GO:0002753
GO:0003677
GO:0003682
GO:0003690
GO:0003824
GO:0005515
GO:0005524
GO:0005525
GO:0005546
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0006281
GO:0006974
GO:0008289
GO:0008340
GO:0016604
GO:0016740
GO:0016779
GO:0019933
GO:0019934
GO:0023052
GO:0031491
GO:0032479
GO:0032481
GO:0035861
GO:0038001
GO:0042803
GO:0043226
GO:0045087
GO:0045738
GO:0046872
GO:0050776
GO:0050863
GO:0051607
GO:0060090
GO:0061501
GO:0071360
GO:0098542
GO:0140693
GO:0140896
GO:0160004
GO:0160049
GO:2000042
GO:2000774
HMNXSV003039938
Hs2.344080.1.S1_3p_s_at
Hs2.344080.2.S1_3p_at
ILMN_1706645
PH_hs_0016662
TC06001873.hg
Participates
as an input of
cGAS binds cytosolic DNA (Homo sapiens)
as a component of
cGAS:dsDNA [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_612450.2
Guide to Pharmacology - Targets
3165
OpenTargets
ENSG00000164430
ENSEMBL
ENST00000370318
,
ENST00000370315
,
ENSP00000359342
,
ENSP00000359339
HPA
ENSG00000164430-CGAS
PRO
Q8N884
Pharos - Targets
Q8N884
HMDB Protein
HMDBP11634
PDB
7C0M
,
5VDS
,
6CTA
,
5VDQ
,
7FUH
,
7FUQ
,
7FUK
,
7FUL
,
7FTO
,
7FU9
,
7FU0
,
7FTN
,
7FU7
,
7CCQ
,
7FUE
,
7FTF
,
7FUC
,
6EDB
,
4LEV
,
7FU5
,
7FTJ
,
7FU3
,
6LRJ
,
6NFG
,
4O69
,
6MJW
,
8SHZ
,
6NAO
,
6CT9
,
5VDP
,
5VDV
,
7FUI
,
7FUN
,
7FUM
,
6Y5E
,
7FTP
,
6NFO
,
7CCR
,
4MKP
,
7FTY
,
6LRC
,
7FTS
,
4LEW
,
7FTQ
,
6LRI
,
6LRL
,
5V8O
,
7FTK
,
8SI0
,
8IMF
,
5VDO
,
5VDU
,
7FUF
,
4KM5
,
6O47
,
7FUO
,
7FTW
,
7FUJ
,
7FTU
,
6Y5D
,
7FU6
,
7FU1
,
7FTG
,
6LRE
,
7FUB
,
7FTZ
,
8WR8
,
7FU4
,
7FU2
,
7FTL
,
6LRK
,
4O67
,
6MJU
,
8IMG
,
5VDT
,
7FUG
,
5VDR
,
5VDW
,
7FUP
,
7FUA
,
8OKX
,
7FUR
,
7FU8
,
7FTM
,
7FTX
,
7FUD
,
7FTV
,
8OL1
,
8SJ8
,
7FTH
,
7FTT
,
7FTI
,
6EDC
,
7FTR
,
4O68
,
6MJX
,
8IME
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