Reactome | SUMO1-K10-TFAP2A-1 [nucleoplasm]

SUMO1-K10-TFAP2A-1 [nucleoplasm]

Stable Identifier

R-HSA-3234080

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO1 N-glycyl-lys10 TFAP2A-1, Transcription factor AP-2-alpha, AP2A_HUMAN, TFAP2A

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
      - Negative regulation of activity of TFAP2 (AP-2) family transcription factors (Homo sapiens)
        
        SUMOylation of TFAP2A with SUMO1 (Homo sapiens)
        
        SUMO1:TFAP2A-1 homodimer [nucleoplasm] (Homo sapiens)
        
        SUMO1-K10-TFAP2A-1 [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of transcription factors (Homo sapiens)
        
        SUMOylation of TFAP2A with SUMO1 (Homo sapiens)
        
        SUMO1:TFAP2A-1 homodimer [nucleoplasm] (Homo sapiens)
        
        SUMO1-K10-TFAP2A-1 [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
12072434	Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo Eloranta, JJ, Hurst, HC	J. Biol. Chem.	2002
21375726	Alternative TFAP2A isoforms have distinct activities in breast cancer Berlato, C, Hurst, HC, Scibetta, AG, Chan, KV, Price, AM, Canosa, M	Breast Cancer Res.	2011

External Reference Information

External Reference

UniProt:P05549-1 TFAP2A

Gene Names

TFAP2A, AP2TF, TFAP2

Other Identifiers

11740388_a_at

11743641_x_at

11743642_s_at

11749049_a_at

11753337_a_at

11761468_at

11761714_at

204653_PM_at

204653_at

204654_PM_s_at

204654_s_at

210669_PM_at

210669_at

2941480

2941481

2941482

2941483

2941484

2941485

2941486

2941487

2941488

2941489

2941490

2941491

2941492

2941493

2941494

2941495

2941496

2941497

2941498

2941499

2941500

2941501

2941502

2941503

2941504

2941507

2941508

2941509

2941510

2941511

2941512

2941513

2941514

2941516

2941517

2941518

2941520

2941521

2941522

2941523

2941525

2941526

2941527

2941537

2941541

32154_at

32155_at

7020

792_s_at

8123864

A_32_P14187

A_33_P3361546

A_33_P3378056

GE81248

GO:0000122

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0001822

GO:0003404

GO:0003409

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0007605

GO:0008285

GO:0010628

GO:0010842

GO:0010944

GO:0021559

GO:0021623

GO:0030501

GO:0035115

GO:0042127

GO:0042472

GO:0042802

GO:0043066

GO:0043226

GO:0043525

GO:0043565

GO:0045595

GO:0045892

GO:0045893

GO:0045944

GO:0048701

GO:0048856

GO:0050877

GO:0060021

GO:0060090

GO:0060349

GO:0061029

GO:0070172

GO:0071281

GO:0140110

GO:0140536

GO:1990837

GO:2000378

HMNXSV003018887

HMNXSV003037677

Hs.18387.0.S2_3p_at

ILMN_1765574

ILMN_2275760

ILMN_2282477

ILMN_2374115

M61156_at

PH_hs_0023068

TC06001260.hg

X52611_s_at

g178704_3p_at

g4507440_3p_a_at

Participates

as a component of

SUMO1:TFAP2A-1 homodimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TFAP2A-1 [nucleoplasm]

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 10

Coordinate

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

ENSEMBL

ENSP00000316516, ENST00000379608, ENST00000319516, ENSP00000368928, ENSG00000137203

OpenTargets

ENSG00000137203

GeneCards

TFAP2A

HPA

ENSG00000137203-TFAP2A

PRO

P05549

Pharos - Targets

P05549

GlyGen

P05549

Orphanet

TFAP2A

PDB

8J0K, 8J0L, 8J0R

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4Y5 GSTO2	1	GSTO2 [cytosol] (R-HSA-176066)	0.666	4
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944)	0.646	4
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.591	6
UniProt:Q86TX2 ACOT1	1	ACOT1 [cytosol] (R-HSA-2066771)	0.564	2
UniProt:Q13064 MKRN3			0.556	3
UniProt:P06429 VE7			0.553	2
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.508	7
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.499	2