Reactome | TFAP2A-1 [nucleoplasm]

TFAP2A-1 [nucleoplasm]

Stable Identifier

R-HSA-3234077

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TFAP2A isoform 1, Transcription factor AP-2-alpha, AP2A_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
      - Negative regulation of activity of TFAP2 (AP-2) family transcription factors (Homo sapiens)
        
        SUMOylation of TFAP2A with SUMO1 (Homo sapiens)
        
        TFAP2A-1 homodimer [nucleoplasm] (Homo sapiens)
        
        TFAP2A-1 [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of transcription factors (Homo sapiens)
        
        SUMOylation of TFAP2A with SUMO1 (Homo sapiens)
        
        TFAP2A-1 homodimer [nucleoplasm] (Homo sapiens)
        
        TFAP2A-1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05549-1 TFAP2A

Gene Names

TFAP2A, AP2TF, TFAP2

Other Identifiers

11740388_a_at

11743641_x_at

11743642_s_at

11749049_a_at

11753337_a_at

204653_PM_at

204653_at

204654_PM_s_at

204654_s_at

2941482

2941483

2941484

2941485

2941486

2941487

2941488

2941489

2941490

2941495

2941496

2941499

2941502

2941503

2941504

2941509

2941510

2941511

2941512

2941513

2941514

2941525

2941526

2941527

32154_at

7020

792_s_at

8123864

A_32_P14187

A_33_P3361546

GE81248

GO:0000122

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0001822

GO:0003404

GO:0003409

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0006357

GO:0007605

GO:0008285

GO:0010628

GO:0010842

GO:0010944

GO:0012501

GO:0021559

GO:0021623

GO:0030154

GO:0030501

GO:0035115

GO:0042127

GO:0042472

GO:0042802

GO:0043066

GO:0043226

GO:0043525

GO:0043565

GO:0045595

GO:0045892

GO:0045893

GO:0045944

GO:0048701

GO:0048856

GO:0050877

GO:0060021

GO:0060349

GO:0061029

GO:0070172

GO:0071281

GO:0140110

GO:0140536

GO:1990837

GO:2000378

HMNXSV003018887

Hs.18387.0.S2_3p_at

ILMN_1765574

ILMN_2275760

ILMN_2374115

PH_hs_0023068

TC06001260.hg

X52611_s_at

g4507440_3p_a_at

Participates

as a component of

TFAP2A-1 homodimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

SUMO1-K10-TFAP2A-1 [nucleoplasm]

Cross References

RefSeq

NP_001027451.1, NP_003211.1, NP_001035890.1

OpenTargets

ENSG00000137203

HPA

ENSG00000137203-TFAP2A

GeneCards

P05549

Ensembl

ENST00000379608, ENST00000319516, ENSP00000368928, ENSP00000316516, ENSG00000137203

PRO

P05549

Pharos - Targets

P05549

Orphanet

17423

PDB

8J0K, 8J0R, 8J0L

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4Y5 GSTO2	1	GSTO2 [cytosol] (R-HSA-176066)	0.666	4
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.646	4
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.591	6
UniProt:Q86TX2 ACOT1	1	ACOT1 [cytosol] (R-HSA-2066771)	0.564	2
UniProt:Q13064 MKRN3			0.556	3
UniProt:P06429 VE7			0.553	2
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.508	7
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.499	2