Reactome | GDF2 [extracellular region]

GDF2 [extracellular region]

Stable Identifier

R-HSA-3222335

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

BMP9, Growth/differentiation factor 2, Bone morphogenetic protein 9, GDF-2, BMP-9

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by BMP (Homo sapiens)
    - ACVRL1 binds BMP9,BMP10 (Homo sapiens)
      - ACVRL1:GDF2 dimer, BMP10 dimer [plasma membrane] (Homo sapiens)
        
        GDF2 dimer, BMP10 dimer [extracellular region] (Homo sapiens)
        
        GDF2 dimer [extracellular region] (Homo sapiens)
        
        GDF2 [extracellular region] (Homo sapiens)
      - GDF2 dimer, BMP10 dimer [extracellular region] (Homo sapiens)
        
        GDF2 dimer [extracellular region] (Homo sapiens)
        
        GDF2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UK05 GDF2

Gene Names

GDF2, BMP9

Chain

signal peptide:1-22, propeptide:23-319, chain:320-429

Reference Genes

BioGPS Gene:2658 GDF2

CTD Gene:2658 GDF2

dbSNP Gene:2658 GDF2

ENSEMBL:ENSG00000263761.3 GDF2

HGNC:4217 GDF2

KEGG Gene (Homo sapiens):2658 GDF2

Monarch:2658 GDF2

NCBI Gene:2658 GDF2

OMIM:605120 GDF2

UCSC:Q9UK05 GDF2

Reference Transcript

RefSeq:NM_016204.3 GDF2

Other Identifiers

0003710593

11741481_at

16713872

221136_PM_at

221136_at

2658

3287779

3287780

3287782

3287783

3287784

3287785

3287786

3287787

3287788

7933366

A_23_P46755

GE80689

GO:0001503

GO:0001525

GO:0001569

GO:0001570

GO:0001649

GO:0001937

GO:0001938

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0006260

GO:0006351

GO:0006355

GO:0006366

GO:0006879

GO:0008083

GO:0008156

GO:0010596

GO:0010628

GO:0010862

GO:0016525

GO:0023052

GO:0030154

GO:0030308

GO:0030509

GO:0030513

GO:0032757

GO:0032924

GO:0036211

GO:0043226

GO:0043537

GO:0045603

GO:0045766

GO:0045893

GO:0045944

GO:0048514

GO:0048856

GO:0048870

GO:0051216

GO:0055065

GO:0060389

GO:0060395

GO:0061036

GO:0070062

GO:0071773

GO:0098772

GO:2000279

HMNXSV003026709

ILMN_1711349

ILMN_1760363

PH_hs_0014351

TC10001251.hg

g7705307_3p_at

Participates

as a component of

GDF2 dimer [extracellular region] (Homo sapiens)

Inferred To

GDF2 [extracellular region] (Bos taurus)

GDF2 [extracellular region] (Canis familiaris)

GDF2 [extracellular region] (Sus scrofa)

mav [extracellular region] (Drosophila melanogaster)

Homologues of GDF2 [extracellular region] (Drosophila melanogaster)

gdf2 [extracellular region] (Danio rerio)

gdf2 [extracellular region] (Xenopus tropicalis)

DSL1 [extracellular region] (Gallus gallus)

Gdf2 [extracellular region] (Mus musculus)

Gdf2 [extracellular region] (Rattus norvegicus)

gbb [extracellular region] (Drosophila melanogaster)

dpp [extracellular region] (Drosophila melanogaster)

scw [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_057288.1

OpenTargets

ENSG00000263761

GeneCards

Q9UK05

HPA

ENSG00000263761-GDF2

Ensembl

ENSP00000463051, ENST00000581492, ENSG00000263761

PRO

Q9UK05

Pharos - Targets

Q9UK05

Orphanet

22383

HMDB Protein

HMDBP14512

PDB

4YCG, 4MPL, 4YCI, 1ZKZ, 5HZW, 4FAO, 5I05