Reactome | PHF20 binds TP53 dimethylated on K370 and K382

PHF20 binds TP53 dimethylated on K370 and K382

Stable Identifier

R-HSA-3222259

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        PHF20 binds TP53 dimethylated on K370 and K382 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

PHF20 binds TP53 dimethylated on K370 and K382

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PHF20 binds TP53 (p53) dimethylated at lysine residues K370 and K382 by unidentified protein lysine methyltransferase(s). PHF20 binding interferes with MDM2 binding to TP53, thus resulting in TP53 stabilization (Cui et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22864287	PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53 Cui, G, Park, S, Badeaux, AI, Kim, D, Lee, J, Thompson, JR, Yan, F, Kaneko, S, Yuan, Z, Botuyan, MV, Bedford, MT, Cheng, JQ, Mer, G	Nat. Struct. Mol. Biol.	2012