Reactome | SMYD2 methylates TP53

SMYD2 methylates TP53

Stable Identifier

R-HSA-3222237

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        SMYD2 methylates TP53 (Homo sapiens)

General

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The lysine methyltransferase SMYD2 methylates TP53 (p53) on lysine residue K370, thus repressing TP53 transcriptional activity. The methylation at K370 is inhibited if TP53 is pre-methylated at K372 (Huang et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
17108971	Repression of p53 activity by Smyd2-mediated methylation Huang, J, Perez-Burgos, L, Placek, BJ, Sengupta, R, Richter, M, Dorsey, JA, Kubicek, S, Opravil, S, Jenuwein, T, Berger, SL	Nature	2006