SMYD2 methylates TP53

Stable Identifier
R-HSA-3222237
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMYD2 methylates TP53
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The lysine methyltransferase SMYD2 methylates TP53 (p53) on lysine residue K370, thus repressing TP53 transcriptional activity. The methylation at K370 is inhibited if TP53 is pre-methylated at K372 (Huang et al. 2006).
Literature References
PubMed ID Title Journal Year
17108971 Repression of p53 activity by Smyd2-mediated methylation

Huang, J, Perez-Burgos, L, Placek, BJ, Sengupta, R, Richter, M, Dorsey, JA, Kubicek, S, Opravil, S, Jenuwein, T, Berger, SL

Nature 2006
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Catalyst Activity

lysine N-methyltransferase activity of SMYD2 [nucleoplasm]

Physical Entity
SMYD2 [nucleoplasm] (Homo sapiens)
Activity
lysine N-methyltransferase activity (GO:0016278)
Orthologous Events
SMYD2 methylates TP53 (Bos taurus)
SMYD2 methylates TP53 (Canis familiaris)
SMYD2 methylates TP53 (Danio rerio)
SMYD2 methylates TP53 (Drosophila melanogaster)
SMYD2 methylates TP53 (Mus musculus)
SMYD2 methylates TP53 (Rattus norvegicus)
SMYD2 methylates TP53 (Sus scrofa)
SMYD2 methylates TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2013-03-18)
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