SMYD2 methylates TP53

Stable Identifier
R-HSA-3222237
Type
Reaction
Species
Homo sapiens
Compartment
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The lysine methyltransferase SMYD2 methylates TP53 (p53) on lysine residue K370, thus repressing TP53 transcriptional activity. The methylation at K370 is inhibited if TP53 is pre-methylated at K372 (Huang et al. 2006).

Literature References
PubMed ID Title Journal Year
17108971 Repression of p53 activity by Smyd2-mediated methylation

Jenuwein, T, Richter, M, Huang, J, Opravil, S, Perez-Burgos, L, Sengupta, R, Berger, SL, Placek, BJ, Kubicek, S, Dorsey, JA

Nature 2006
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Participates
Catalyst Activity

lysine N-methyltransferase activity of SMYD2 [nucleoplasm]

Orthologous Events
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