SMYD2 methylates TP53

Stable Identifier
R-HSA-3222237
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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SMYD2 methylates TP53
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The lysine methyltransferase SMYD2 methylates TP53 (p53) on lysine residue K370, thus repressing TP53 transcriptional activity. The methylation at K370 is inhibited if TP53 is pre-methylated at K372 (Huang et al. 2006).

Literature References
PubMed ID Title Journal Year
17108971 Repression of p53 activity by Smyd2-mediated methylation

Huang, J, Perez-Burgos, L, Placek, BJ, Sengupta, R, Richter, M, Dorsey, JA, Kubicek, S, Opravil, S, Jenuwein, T, Berger, SL

Nature 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
lysine N-methyltransferase activity of SMYD2 [nucleoplasm]
Physical Entity
SMYD2 [nucleoplasm]
Activity
lysine N-methyltransferase activity (0016278)
Orthologous Events
SMYD2 methylates TP53 (Bos taurus)
SMYD2 methylates TP53 (Danio rerio)
SMYD2 methylates TP53 (Mus musculus)
SMYD2 methylates TP53 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2013-03-18)