NOC2L binds TP53

Stable Identifier
R-HSA-3222128
Type
Reaction
Species
Homo sapiens
Compartment
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NOC2L (NIR) is an inhibitor of histone acetyltransferases that associates with TP53 (p53). NOC2L binding represses TP53-mediated transcriptional activation at TP53 target genes. One possible mechanism is the prevention of activating histone acetylation at TP53 target genes (Hublitz et al. 2005).

Literature References
PubMed ID Title Journal Year
16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53

Kunowska, N, Miguet, L, Roemer, K, Heyne, K, Yin, N, Potiers, N, Poli, C, Schüle, R, Metzger, E, Müller, JM, Hublitz, P, van Dorsselaer, A, Schupp, IW, Mayer, UP, Fritzsche, C, van Grunsven, LA

Genes Dev. 2005
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Orthologous Events
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