NOC2L binds TP53

Stable Identifier
R-HSA-3222128
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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NOC2L binds TP53
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NOC2L (NIR) is an inhibitor of histone acetyltransferases that associates with TP53 (p53). NOC2L binding represses TP53-mediated transcriptional activation at TP53 target genes. One possible mechanism is the prevention of activating histone acetylation at TP53 target genes (Hublitz et al. 2005).

Literature References
PubMed ID Title Journal Year
16322561 NIR is a novel INHAT repressor that modulates the transcriptional activity of p53

Hublitz, P, Kunowska, N, Mayer, UP, Müller, JM, Heyne, K, Yin, N, Fritzsche, C, Poli, C, Miguet, L, Schupp, IW, van Grunsven, LA, Potiers, N, van Dorsselaer, A, Metzger, E, Roemer, K, Schüle, R

Genes Dev. 2005
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
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NOC2L binds TP53 (Mus musculus)
NOC2L binds TP53 (Rattus norvegicus)
NOC2L binds TP53 (Sus scrofa)
NOC2L binds TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2013-03-18)