Reactome | NOC2L binds TP53

NOC2L binds TP53

Stable Identifier

R-HSA-3222128

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        NOC2L binds TP53 (Homo sapiens)

General

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NOC2L (NIR) is an inhibitor of histone acetyltransferases that associates with TP53 (p53). NOC2L binding represses TP53-mediated transcriptional activation at TP53 target genes. One possible mechanism is the prevention of activating histone acetylation at TP53 target genes (Hublitz et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16322561	NIR is a novel INHAT repressor that modulates the transcriptional activity of p53 Kunowska, N, Miguet, L, Roemer, K, Heyne, K, Yin, N, Potiers, N, Poli, C, Schüle, R, Metzger, E, Müller, JM, Hublitz, P, van Dorsselaer, A, Schupp, IW, Mayer, UP, Fritzsche, C, van Grunsven, LA	Genes Dev.	2005