Reactome | BRD7 binds TP53 and EP300

BRD7 binds TP53 and EP300

Stable Identifier

R-HSA-3222093

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        BRD7 binds TP53 and EP300 (Homo sapiens)

General

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The N-terminal region of BRD7, upstream of its bromodomain that is responsible for interaction with chromatin, binds the C-terminus of TP53 (p53) (Drost et al. 2010, Burrows et al. 2010). BRD7 also binds and can recruit EP300 (p300) to TP53 target promoters CDKN1A and MDM2 (Drost et al. 2010). BRD7 positively regulates transcription of other TP53 targets: SERPINE1, TIGAR (Bensaad et al. 2006), TNFRSF10C and NDGR1, presumably via a similar mechanism as in the case of CDKN1A and MDM2 (Drost et al. 2010, Burrows et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
16839880	TIGAR, a p53-inducible regulator of glycolysis and apoptosis Vidal, MN, Bensaad, K, Selak, MA, Tsuruta, A, Nakano, K, Gottlieb, E, Bartrons, R, Vousden, KH	Cell	2006
20228809	BRD7 is a candidate tumour suppressor gene required for p53 function Tocco, F, Del Sal, G, Drost, J, Elkon, R, Holstege, H, Kerkhoven, R, Mantovani, F, Agami, R, Jonkers, J, Comel, A, Voorhoeve, PM	Nat. Cell Biol.	2010
20660729	Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence Burrows, AE, Elledge, SJ, Smogorzewska, A	Proc. Natl. Acad. Sci. U.S.A.	2010