BRD7 binds TP53 and EP300

Stable Identifier
R-HSA-3222093
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The N-terminal region of BRD7, upstream of its bromodomain that is responsible for interaction with chromatin, binds the C-terminus of TP53 (p53) (Drost et al. 2010, Burrows et al. 2010). BRD7 also binds and can recruit EP300 (p300) to TP53 target promoters CDKN1A and MDM2 (Drost et al. 2010). BRD7 positively regulates transcription of other TP53 targets: SERPINE1, TIGAR (Bensaad et al. 2006), TNFRSF10C and NDGR1, presumably via a similar mechanism as in the case of CDKN1A and MDM2 (Drost et al. 2010, Burrows et al. 2010).

Literature References
PubMed ID Title Journal Year
20228809 BRD7 is a candidate tumour suppressor gene required for p53 function

Drost, J, Mantovani, F, Tocco, F, Elkon, R, Comel, A, Holstege, H, Kerkhoven, R, Jonkers, J, Voorhoeve, PM, Agami, R, Del Sal, G

Nat. Cell Biol. 2010
16839880 TIGAR, a p53-inducible regulator of glycolysis and apoptosis

Bensaad, K, Tsuruta, A, Selak, MA, Vidal, MN, Nakano, K, Bartrons, R, Gottlieb, E, Vousden, KH

Cell 2006
20660729 Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence

Burrows, AE, Smogorzewska, A, Elledge, SJ

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created