Reactome | DAXX binds Ub-MDM2 and USP7

DAXX binds Ub-MDM2 and USP7

Stable Identifier

R-HSA-3222072

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        DAXX binds Ub-MDM2 and USP7 (Homo sapiens)

General

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DAXX paired amphipathic helix domain 2 (PAH2) binds MDM2, while DAXX PAH1 domain and acid rich region simultaneously bind USP7 (HAUSP) (Tang et al. 2006), forming a tripartite complex.

Literature References

PubMed ID	Title	Journal	Year
16845383	Critical role for Daxx in regulating Mdm2 Tang, J, Qu, LK, Zhang, J, Wang, W, Michaelson, JS, Degenhardt, YY, El-Deiry, WS, Yang, X	Nat. Cell Biol.	2006