Reactome | DAXX binds Ub-MDM2 and USP7

DAXX binds Ub-MDM2 and USP7

Stable Identifier

R-HSA-3222072

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        DAXX binds Ub-MDM2 and USP7 (Homo sapiens)

General

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DAXX paired amphipathic helix domain 2 (PAH2) binds MDM2, while DAXX PAH1 domain and acid rich region simultaneously bind USP7 (HAUSP) (Tang et al. 2006), forming a tripartite complex.

Literature References

PubMed ID	Title	Journal	Year
16845383	Critical role for Daxx in regulating Mdm2 Wang, W, Zhang, J, Degenhardt, YY, Tang, J, Qu, LK, Michaelson, JS, Yang, X, El-Deiry, WS	Nat. Cell Biol.	2006